Merck
  • SML0278
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SML0278

Sigma-Aldrich

SR 48692

≥98% (HPLC)

Synonym(s):
2-[[[1-(7-クロロ-4-キノリニル)-5-(2,6-ジメトキシフェニル)-1H-ピラゾル-3-イル]カルボニル]アミノ]-トリシクロ[3.3.1.13,7]デカン-2-カルボン酸, Meclinertant
Empirical Formula (Hill Notation):
C32H31ClN4O5
CAS Number:
Molecular Weight:
587.07
PubChem Substance ID:
NACRES:
NA.77

品質水準

アッセイ

≥98% (HPLC)

形状

powder

white to beige

溶解性

DMSO: ≥2 mg/mL (warmed)

保管温度

−20°C

SMILES string

COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O

InChI

1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)

InChI key

DYLJVOXRWLXDIG-UHFFFAOYSA-N

Gene Information

human ... NTSR1(4923)

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SR 48692 ≥98% (HPLC)

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assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to off-white

color

white to beige

color

white to beige

solubility

DMSO: ≥2 mg/mL (warmed)

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

アプリケーション

SR48692は、ニューロテンシン高親和性受容体1(NTSR1)拮抗薬として、以下の用途に用いられています。
  • 膠芽腫(GBM)細胞におけるNTSR1の機能を検討に
  • in vivoでの胆汁酸(BA)取り込み調節におけるニューロテンシン(NT)の役割の解明
  • マウスにおけるNTSR1とNTSR2の関与の比較検討

生物化学的/生理学的作用

SR 48692は、高親和性かつ経口でバイオアベイラブルであり、選択的な非ペプチドNT1ニューロテンシン受容体アンタゴニストであり、HT-29ヒト大腸癌細胞株においてニューロテンシン誘発カルシウムの動員(pA2 8.13)をアンタゴナイズし、前頭前皮質においてニューロテンシンのGABA上昇能をブロックします。

特徴および利点

この化合物はHandbook of Receptor Classification and Signal Transduction(受容体分類およびシグナル変換ハンドブック)のNeurotensin Receptorsのページに取り上げられています。ハンドブックのその他のページをご覧になるには、ここをクリックしてください

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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