Merck
  • SML0379
All Photos(1)

SML0379

Sigma-Aldrich

Nodinitib-1

≥98% (HPLC)

All Photos(1)
Synonym(s):
1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130
Empirical Formula (Hill Notation):
C14H13N3O2S
CAS Number:
799264-47-4
Molecular Weight:
287.34
MDL番号:
MFCD04322367
PubChem Substance ID:
329825379
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

色

white to beige

溶解性

DMSO: >10 mg/mL

保管温度

2-8°C

SMILES string

NC1=NC2=C(N1S(C3=CC=C(C)C=C3)(=O)=O)C=CC=C2

InChI

1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)

InChI key

SRFABRWQVPCPRG-UHFFFAOYSA-N

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SML1457

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to tan

color

white to tan

color

white to beige

solubility

DMSO: >10 mg/mL

solubility

DMSO: ≥8 mg/mL

solubility

-

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

生物化学的／生理学的作用

Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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