Merck
  • SML0428
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SML0428

Sigma-Aldrich

GSK690693

≥98% (HPLC)

Synonym(s):
4-(2-(4-アミノ-1,2,5-オキサジアゾール-3-イル)-1-エチル-7-{[(3S)-3-ピペリジニルメチル]オキシ} -1H-イミダゾ[4,5-c]ピリジン-4-イル)-2-メチル-3-ブチン-2-オール
Empirical Formula (Hill Notation):
C21H27N7O3
CAS Number:
Molecular Weight:
425.48
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

品質水準

アッセイ

≥98% (HPLC)

形状

powder

white to beige

溶解性

DMSO: 5 mg/mL (clear solution)

保管温度

2-8°C

SMILES string

CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c4nonc4N

InChI

1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

InChI key

KGPGFQWBCSZGEL-ZDUSSCGKSA-N

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

アプリケーション

GSK690693抗体は、ウェスタンブロット法および免疫沈降法に使用されています。

生物化学的/生理学的作用

4-(2-(4-アミノ-1,2,5-オキサジアゾール-3-イル)-1-エチル-7-{[(3S)-3-ピペリジニルメチル]オキシ}AKT-1H-イミダゾ[4,5-c]ピリジン-4-イル)-2-メチル-3-ブチン-2-オール/GSK690693は、プロテインキナーゼB/AKT阻害剤です。 GSK690693は、急性リンパ芽球性白血病細胞株の増殖とアポトーシスを防止できます。
GSK690693は、AKT1、2、3に対してそれぞれ2、13、9 nMのIC50値を示す、ATP競合性の強力なpan-AKTキナーゼ阻害剤です。

特徴および利点

本化合物は、Handbook of Receptor Classification and Signal TransductionのPKB/Aktのページに収載されています。ハンドブックのその他のページを閲覧するには、ここをクリックしてください

ピクトグラム

Skull and crossbones

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Acute Tox. 3 Oral

保管分類コード

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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