SML0440

Sigma-Aldrich

スパウチン-1

≥98% (HPLC)

別名:
C43, 6-フルオロ-N-[(4-フルオロフェニル)メチル]-4-キナゾリンアミン
Empirical Formula (Hill Notation):
C15H11F2N3
CAS番号:
分子量:
271.26
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形態

powder

white to beige

溶解性

DMSO: 15 mg/mL (clear solution)

保管温度

2-8°C

SMILES string

Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1

InChI

1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)

InChI key

AWIVHRPYFSSVOG-UHFFFAOYSA-N

アプリケーション

Spautin-1 has been used as an autophagy inhibitor:
  • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
  • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
  • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

包装

5, 25 mg in glass bottle

生物化学的/生理学的作用

Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.
スパウチン-1は2種類のユビキチン特異的ペプチダーゼUSP10とUSP13の活性を阻害し、これにより、オートファジーの制御を示すクラスIII PI3キナーゼ複合体のプロテアソーム分解が亢進します。

ピクトグラム

CorrosionExclamation mark

シグナルワード

Danger

危険有害性情報

hazcat

Acute Tox. 4 Oral - Eye Dam. 1

storage_class_code

11 - Combustible Solids

ドイツ水質汚染分類

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)

原産地証明書(COO)

その他のドキュメント

Leonhard H Urner et al.
Nature communications, 11(1), 564-564 (2020-01-30)
Detergents enable the purification of membrane proteins and are indispensable reagents in structural biology. Even though a large variety of detergents have been developed in the last century, the challenge remains to identify guidelines that allow fine-tuning of detergents for...
Z Solhjou et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 17(9), 2326-2337 (2017-03-16)
Ischemia-reperfusion injury (IRI) evokes intragraft inflammatory responses, which markedly augment alloimmune responses against the graft. Understanding the mechanisms underlying these responses is fundamental to develop therapeutic regimens to prevent/ameliorate organ IRI. Here, we demonstrate that IRI results in a marked...
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination...
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid...
Dirk Mohn et al.
PloS one, 6(1), e16157-e16157 (2011-01-26)
Peri-implantitis has gained significant clinical attention in recent years. This disease is an inflammatory reaction to microorganisms around dental implants. Due to the limited accessibility, non-invasive antimicrobial strategies are of high interest. An unexpected approach to implant disinfection may evolve...

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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