Merck
  • SML0714
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SML0714

Sigma-Aldrich

FSLLRY-NH2 トリフルオロアセタート塩

≥98% (HPLC)

Empirical Formula (Hill Notation):
C39H60N10O8 · xC2HF3O2
CAS Number:
Molecular Weight:
796.96 (free base basis)

品質水準

アッセイ

≥98% (HPLC)

形状

powder

white to off-white

輸送温度

wet ice

保管温度

−20°C

InChI

1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1

InChI key

KMSCNWHRNILNRJ-JNRWAQIZSA-N

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This Item
SML0648F9932E3285
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to off-white

color

white to beige

color

yellow

color

white

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Amino Acid Sequence

Phe-Ser-Leu-Leu-Arg-Tyr-NH2 trifluoroacetate salt

アプリケーション

FSLLRY-NH2トリフルオロ酢酸塩は、マウスモデルの尿路感染症(UTI)に対する影響を検討するために、プロテアーゼ活性化受容体2(PAR2)阻害薬として使用されています。ラットにおける、アトピー性皮膚炎(AD)関連急性そう痒フレアマウスモデルの、中等度から重度のADに関する第3相臨床試験の臨床的そう痒データセットの検討に使用されています。

生物化学的/生理学的作用

FSLLRY-NH2が内臓過敏症(VH)を減少させる能力から、PAR2がVHの維持に関与していることが示唆されています。
FSLLRY-NH2は、プロテアーゼ活性化受容体2(PAR2)のペプチドアンタゴニストです。ペプチドは、げっ歯類モデルでアゴニストが誘発するそう痒を阻害します。細胞ベースのアッセイでは、ペプチドはアゴニスト誘発性の心筋細胞再構築、および内皮細胞によるサイトカインの産生を阻害します。

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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