Merck
  • SML0737
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SML0737

Sigma-Aldrich

MitoTEMPO

≥98% (HPLC)

Synonym(s):
Mito-TEMPO, (2-(2,2,6,6-テトラメチルピペリジン-1-オキシル-4-イルアミノ)-2-オキソエチル)トリフェニルホスホニウム塩化物
Empirical Formula (Hill Notation):
C29H35N2O2P · Cl
CAS Number:
Molecular Weight:
510.03
NACRES:
NA.77

品質水準

アッセイ

≥98% (HPLC)

形状

powder

保管条件

desiccated
protect from light

white to light brown

溶解性

H2O: 10 mg/mL, clear

保管温度

−20°C

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MitoTEMPO ≥98% (HPLC)

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SML1885

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Sigma-Aldrich

SML1300

MitoB

MitoPQ ≥90% (HPLC)

Sigma-Aldrich

SML3152

MitoPQ

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

storage condition

desiccated

color

white to light brown

color

white to beige

color

white to beige

color

brown to brown-red

solubility

H2O: 10 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

アプリケーション

MitoTEMPOはミトコンドリア標的抗酸化剤として使用されています。

生物化学的/生理学的作用

Mito TEMPOは、ミトコンドリアを標的とする抗酸化剤で、ミトコンドリアスーパーオキシドの特異的スカベンジャーです。 Mito TEMPOは、抗酸化剤ピペリジンニトロキシドTEMPOと親油性陽イオントリフェニルホスホニウムを組み合わせたものであることから、MitoTEMPOは脂質二重層を容易に通過でき、ミトコンドリア内に数百倍蓄積されます。 ミトコンドリア機能不全および酸化的ストレスが、心血管、腎、肝障害、パーキンソン病およびアルツハイマー病などのさまざまな障害の一因となります。

その他情報

光感受性

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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