Merck
  • SML0796
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SML0796

Sigma-Aldrich

HI-TOPK-032

≥98% (HPLC)

All Photos(1)
Synonym(s):
N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
Empirical Formula (Hill Notation):
C20H11N5OS
CAS Number:
487020-03-1
Molecular Weight:
369.40
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

色

orange to dark red

溶解性

DMSO: 3 mg/mL, clear (warmed)

保管温度

2-8°C

InChI

1S/C20H11N5OS/c21-11-13-16-10-12(22-20(26)17-6-3-9-27-17)7-8-25(16)19-18(13)23-14-4-1-2-5-15(14)24-19/h1-10H,(H,22,26)

InChI key

BCSBXWKRZUPFHW-UHFFFAOYSA-N

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SML0224

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

orange to dark red

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

H2O: 15 mg/mL (clear solution)

solubility

DMSO: 15 mg/mL, clear

solubility

H2O: 10 mg/mL, clear, DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

アプリケーション

HI-TOPK-032 has been used as a PDZ binding-kinase (PBK) inhibitor.

生物化学的／生理学的作用

HI-TOPK-032 belongs to the class of ATP-competitive inhibitors. It can also be used as a potent therapeutic for colorectal cancer.
HI-TOPK-032 is a specific TOPK (T-LAK cell–originated protein kinase) inhibitor both in vitro and in vivo. HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

劇物

JAN Code

SML0796-25MG:4.548173338668E12
SML0796-5MG:4.548173338675E12

Certificate of Analysis

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Certificate of Origin

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