Merck
  • SML0832
All Photos(1)

SML0832

Sigma-Aldrich

TLR4-IN-C34

≥98% (HPLC)

All Photos(1)
Synonym(s):
2-Acetamidopyranoside, C34, Isopropyl 2-(acetylamino)-2-deoxy α-D-glucopyranoside 3,4,6-triacetate
Empirical Formula (Hill Notation):
C17H27NO9
CAS Number:
40592-88-9
Molecular Weight:
389.40
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

保管条件

desiccated

色

white to beige

溶解性

H2O: 1 mg/mL, clear (warmed)

保管温度

−20°C

InChI

1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1

InChI key

KMIQMFHPUJUDMC-HHARLNAUSA-N

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Sigma-Aldrich

5.08336

InSolution TLR4 Inhibitor, TAK-242

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

liquid

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

color

white to beige

color

white to beige

color

white to beige

color

-

solubility

H2O: 1 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−70°C

詳細

TLR4-IN-C34 is an inhibitor of toll-like receptor 4 (TLR4) in vitro and in vivo.

アプリケーション

TLR4-IN-C34 has been used as an inhibitor in the HFD-feeding mice to verify the aforementioned in vitro pathway (stearic acid/LDH-a/cytokines) in vivo.

生物化学的／生理学的作用

TLR4-IN-C34 is a potent and specific inhibitor of toll-like receptor 4 (TLR4), which inhibits TLR4 signaling in vivo and in vitro. TLR4-IN-C34, also known as C34, is an aminomonosaccharide that inhibits TLR4 signaling by docking with the hydrophobic pocket of the TLR4 co-receptor, myeloid differentiation protein-2 (MD-2). C34 has been shown to diminish the severity of experimental necrotizing enterocolitis (NEC).

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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