Merck
  • SML0897
All Photos(1)

SML0897

Sigma-Aldrich

ALX 5407 塩酸塩

≥98% (HPLC)

All Photos(1)
Synonym(s):
(±)-NFPS 塩酸塩, N-[3-(4'-フルオロフェニル)-3-(4'-フェニルフェノキシ)プロピル]サルコシン 塩酸塩
Empirical Formula (Hill Notation):
C24H24NO3F·HCl
CAS Number:
200006-08-2
Molecular Weight:
429.91
MDL番号:
MFCD09971056
PubChem Substance ID:
329825613
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

保管条件

desiccated

色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

保管温度

2-8°C

SMILES string

Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O

InChI

1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1

InChI key

RPDGSZCYSJWQEE-GNAFDRTKSA-N

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ALX 5407 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0897

ALX 5407 塩酸塩

NLX-112 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML2324

NLX-112 hydrochloride

BX-795 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0694

BX-795 塩酸塩

Alosetron hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0346

Alosetron hydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

desiccated

color

white to beige

color

white to beige

color

white to light brown

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

H2O: ≥5 mg/mL at warmed

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

アプリケーション

ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.

生物化学的／生理学的作用

ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

ピクトグラム

Exclamation markEnvironment
GHS07,GHS09

シグナルワード

Warning

危険有害性情報

H302 - H410

危険有害性の分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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