SML1224
Torin2
≥98% (HPLC), mTOR inhibitor, powder
別名:
9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
5 mg | カートの在庫状況を確認する | ￥32,000 |
25 mg | カートの在庫状況を確認する | ￥69,800 |
この商品について
Assay:
≥98% (HPLC)
Form:
powder
製品名
Torin2, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N
InChI
1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
InChI key
GUXXEUUYCAYESJ-UHFFFAOYSA-N
Application
Torin2 has been used:
- to examine its effect on LC3B-II levels in BORCS5- KO cells
- to determine its potent activity (IC50 less than 1 μM) against A2780-cis ovarian cancer cells
- in western blot analysis
Biochem/physiol Actions
Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.
Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.
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当該品目 | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥99% (HPLC) | assay ≥99% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: 10 mg/mL | solubility DMSO: 2 mg/mL | solubility DMSO: 10 mg/mL, clear (warmed) |
| color white to beige | color yellow | color yellow-white | color white to beige |
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable