Merck
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SML1825

Sigma-Aldrich

GSK984

≥98% (HPLC)

All Photos(1)
Synonym(s):
N-[(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide
Empirical Formula (Hill Notation):
C18H16ClN3O
CAS Number:
827591-04-8
Molecular Weight:
325.79
PubChem Substance ID:
329826083

アッセイ

≥98% (HPLC)

形状

powder

光学活性

[α]/D -175 to -195°, c = 1 in methylene chloride

保管条件

protect from light

色

white to beige

溶解性

DMSO: 20 mg/mL, clear

保管温度

2-8°C

SMILES string

ClC1=CC=C(NC2=C3CCC[C@@H]2NC(C4=NC=CC=C4)=O)C3=C1

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GSK984 ≥98% (HPLC)

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Sigma-Aldrich

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GSK2334470 ≥98% (HPLC)

Sigma-Aldrich

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage condition

protect from light

storage condition

-

storage condition

-

storage condition

-

color

white to beige

color

colorless to very dark brown

color

white to beige

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

生物化学的／生理学的作用

GSK984 is an inactive control probe for GSK983, which is an inhibitor of dihydroorotate dehydrogenase (DHODH) with antiviral activity. GSK983 blocks RNA virus replication with EC50 values of 10–40 nM, and also blocks cell proliferation. GSK984 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses. GSK984, the (S)-isomer, is almost 200-fold less active, so would make a good control.

ピクトグラム

Exclamation mark
GHS07

シグナルワード

Warning

危険有害性情報

H302 - H315 - H319

危険有害性の分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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