Merck
  • SML1866
All Photos(1)

SML1866

Sigma-Aldrich

KIN1408

≥98% (HPLC)

All Photos(1)
Synonym(s):
7-((4-(Difluoromethoxy)phenyl)(5-methoxybenzo[d]thiazol-2-ylamino)methyl)quinolin-8-ol, 7-[[4-(Difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-8-quinolinol
Empirical Formula (Hill Notation):
C25H19F2N3O3S
CAS Number:
1903800-11-2
Molecular Weight:
479.50
MDL番号:
MFCD29924731
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

色

white to beige

溶解性

DMSO: 30 mg/mL, clear

保管温度

2-8°C

SMILES string

OC(C(N=CC=C1)=C1C=C2)=C2C(C3=CC=C(OC(F)F)C=C3)NC4=NC5=C(S4)C=CC(OC)=C5

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KIN1408 ≥98% (HPLC)

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KIN1408

KN-93 ≥98% (HPLC)

Sigma-Aldrich

K1385

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Kinetin ≥99.0% (HPLC)

Sigma-Aldrich

48130

キネチン

Ki 16425 ≥98% (HPLC)

Sigma-Aldrich

SML0971

Ki 16425

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99.0% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

-

form

powder

color

white to beige

color

white

color

-

color

white to beige

solubility

DMSO: 30 mg/mL, clear

solubility

DMSO: 1 mg/mL, H2O: soluble

solubility

-

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

生物化学的／生理学的作用

KIN1408 is a small molecule that targets factors at or above the level of MAVS in the RLR signaling pathway to drive IRF3 activation (IRF3 nuclear translocation ECmax = 5 μM in 20 h; Huh7 cells) without significant cytotoxicity (50 μM/20 h in Huh7 or 20 μM/36 h in HEK293 cultures). KIN1408 induces cellular transcription of innate immune genes (Eff. conc. 1.25-20 μM in 20 h; PMA-differentiated THP-1 cells) in a MAVS- and IRF3-dependent manner and exhibits broad-spectrum anti-viral activity (Eff. conc. 1-5 μM), including dengue virus 2 (DV2; Huh7), influenza A (IAV H3N2; HEK293), RSV (A2 strain; HeLa), Ebola (EBOV strain Zaire; HUVECs), Nipah virus (NiV; HUVECs), and Lassa virus (LASV; HUVECs). MAVS signaling activation upon Zika virus infection or KIN1408 treatment is reported to result in pTBK1 mitochondria relocalization and caspase 3-mediated apoptosis in human neuroepithelial stem (NES) cells.

危険有害性情報

H413

注意書き

P273 - P501

危険有害性の分類

Aquatic Chronic 4

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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