Merck
All Photos(1)

SML1876

Sigma-Aldrich

PaPE-1

≥98% (HPLC)

All Photos(1)
Synonym(s):
(S)-5-(4-Hydroxy-3,5-dimethyl-phenyl)-indan-1-ol
Empirical Formula (Hill Notation):
C17H18O2
Molecular Weight:
254.32
MDL番号:
MFCD30723184

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

色

white to beige

溶解性

DMSO: 25 mg/mL, clear

保管温度

2-8°C

SMILES string

O[C@H]1CCC2=C1C=CC(C3=CC(C)=C(O)C(C)=C3)=C2

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TP-472 ≥98% (HPLC)

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SML1862

TP-472

PFI-6N ≥98% (HPLC)

Sigma-Aldrich

SML3066

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

生物化学的／生理学的作用

PaPE-1 is a "Pathway Preferential Estrogen" that activates the extranuclear signaling pathway without activating the nuclear signaling pathway. PaPE-1 bound 50,000-fold less well to ERα and Erβ estrogen receptors. PaPE-1 activated extranuclear-initiated ER-regulated genes, but showed essentially no activation of nuclear-initiated estrogen receptor (ER) gene targets such as the progesterone receptor. Unlike estradiol (E2), PaPE-1 did not stimulate proliferation of MCF-7 breast cancer cells. Like estradiol, PaPE-1 strongly activated MAPK and mTOR pathway. Instead, it showed preferential estrogen-like activity in non-reproductive (metabolic and vascular) tissues, reducing body weight gain and fat accumulation in ovariectomized mice and accelerating repair of endothelial damage in the vascualture.

ピクトグラム

Exclamation mark
GHS07

シグナルワード

Warning

危険有害性情報

H315 - H319

危険有害性の分類

Eye Irrit. 2 - Skin Irrit. 2

保管分類コード

11 - Combustible Solids

WGK

WGK 3

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