Merck
  • SML2216
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SML2216

Sigma-Aldrich

Takinib

≥98% (HPLC)

All Photos(1)
Synonym(s):
N1-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
Empirical Formula (Hill Notation):
C18H18N4O2
CAS Number:
1111556-37-6
Molecular Weight:
322.36
NACRES:
NA.77

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TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

Sigma-Aldrich

614316

TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem

TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

5Z-7-Oxozeaenol ≥98% (HPLC)

Sigma-Aldrich

O9890

5Z-7-オキソゼアエノール

≥98% (HPLC)

(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).

Sigma-Aldrich

499610

(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).

BX-795 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0694

BX-795 塩酸塩

≥98% (HPLC)

NG25 trihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1332

NG25 trihydrochloride

≥98% (HPLC)

GSK8612 ≥98% (HPLC)

Sigma-Aldrich

SML2721

GSK8612

≥98% (HPLC)

InSolution TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem

Sigma-Aldrich

5.08336

InSolution TLR4 Inhibitor, TAK-242 - CAS 243984-11-4 - Calbiochem

Sigma-Aldrich

Sigma-Aldrich

SRP3058

IFN-γ ヒト

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Tofacitinib citrate ≥98% (HPLC)

Sigma-Aldrich

PZ0017

トファシチニブクエン酸塩

≥98% (HPLC)

Necrostatin-1 - CAS 4311-88-0 - Calbiochem Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).

Sigma-Aldrich

480065

Necrostatin-1 - CAS 4311-88-0 - Calbiochem

Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).

アッセイ

≥98% (HPLC)

形状

powder

色

white to beige

溶解性

DMSO: 2 mg/mL, clear

保管温度

2-8°C

SMILES string

CCCN1C2=CC=CC=C2N/C1=N\C(C3=CC(C(N)=O)=CC=C3)=O

詳細

Takinib belongs to the aminobenzimidazole class of inhibitors.

アプリケーション

Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.

包装

5, 25 mg

生物化学的／生理学的作用

Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

Certificate of Analysis

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Certificate of Origin

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