SML2259

ラパチニブ

≥98% (HPLC)

• Synonym(s): ラパチニブ, GD 2016, GSK 572016, GW-572016, GW572016, N-(3-クロロ-4-((3-フルオロフェニル)メトキシ)フェニル)-6-(5-(((2-(メチルスルホニル)エチル)アミノ)メチル)-2-フラニル)-4-キナゾリナミン, N-(3-クロロ-4-((3-フルオロフェニル)メトキシ)フェニル)-6-(5-((2-メチルスルホニルエチルアミノ)メチル)-2-フリル)キナゾリン-4-アミン
• Empirical Formula (Hill Notation): C₂₉H₂₆ClFN₄O₄S
• CAS Number: 231277-92-2
• Molecular Weight: 581.06
• MDL番号: MFCD09264194
• NACRES: NA.77

Properties

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES string: CS(=O)(CCNCC1=CC=C(C2=CC=C3N=CN=C(C3=C2)NC4=CC=C(C(Cl)=C4)OCC5=CC=CC(F)=C5)O1)=O
• InChI: 1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
• InChI key: BCFGMOOMADDAQU-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956) , ERBB2(2064)

Description

生物化学的／生理学的作用

Lapatinib acts as a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 (HER2/ErbB2). It competes for its binding site on the tyrosine kinase domain with adenosine triphosphate (ATP). Lapatinib mediates has been studied in vitro in the inhibition of cell growth as well as and apoptosis induction in several human cancer cells such as breast, lung, vulva, gastric, and head and neck cancer.

Safety Information

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319 - H362 - H413
• 注意書き: P201 - P260 - P263 - P273 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Aquatic Chronic 4 - Eye Irrit. 2 - Lact.
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable