Merck
  • SML2664
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SML2664

Sigma-Aldrich

GNF-4877

≥98% (HPLC)

Synonym(s):
(3R)-1-[3-[[[3-Amino-6-[2-fluoro-5-(1-methylethoxy)phenyl]-2-pyrazinyl]carbonyl]amino]-4-pyridinyl]-3-piperidinecarboxylic acid, GNF 4877
Empirical Formula (Hill Notation):
C25H27FN6O4
CAS Number:
Molecular Weight:
494.52

アッセイ

≥98% (HPLC)

形状

powder

faint yellow to dark orange

溶解性

DMSO: 2 mg/mL, clear

保管温度

2-8°C

SMILES string

NC1=NC=C(C2=CC(OC(C)C)=CC=C2F)N=C1C(NC3=CN=CC=C3N4C[C@H](C(O)=O)CCC4)=O

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GNF-4877 ≥98% (HPLC)

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GNF-5 ≥98% (HPLC)

Sigma-Aldrich

SML0511

GNF-5

GNF-2 ≥98% (HPLC), solid

Sigma-Aldrich

G9420

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GK921 ≥98% (HPLC)

Sigma-Aldrich

SML3321

GK921

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

solid

form

powder

color

faint yellow to dark orange

color

white to beige

color

off-white

color

, Faint yellow to very dark orange

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL (clear solution)

solubility

H2O: <2 mg/mL, DMSO: ≥5 mg/mL

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

生物化学的/生理学的作用

GNF-4877 is an orally available dual inhibitor of Dyrk1a and Gsk3b that induces proliferation of functional primary human and rodent β-cells. GNF4877 reduces non-fasting blood glucose levels in a mouse model of T1D.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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