Merck
  • SML2704
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SML2704

Sigma-Aldrich

BAY-294

≥98% (HPLC)

Synonym(s):
BAY-294, 6,7-Dimethoxy-2-methyl-N-[(S)-1-(4-{2-[(methylamino)methyl]phenyl}thien-2-yl)ethyl]quinazolin-4-amine, BAY 293 (S)-enantiomer, BAY 293 control, BAY 294, BAY-293 (S)-enantiomer, BAY-293 control, BAY293 (S)-enantiomer, BAY293 control, BAY294
Empirical Formula (Hill Notation):
C25H28N4O2S
CAS Number:
Molecular Weight:
448.58

品質水準

アッセイ

≥98% (HPLC)

形状

powder

光学活性

[α]/D +86.0 to +106.0°, c = 1.0 in DMSO

white to beige

溶解性

DMSO: 2 mg/mL, clear

保管温度

−20°C

SMILES string

C[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC

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BAY-294 ≥98% (HPLC)

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BAY-899 ≥98% (HPLC)

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BAY-390 ≥98% (HPLC)

Sigma-Aldrich

SML3306

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BAY-207 ≥98% (HPLC)

Sigma-Aldrich

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BAY-207

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

oil

form

powder

color

white to beige

color

white to beige

color

yellow to orange

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 1 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

生物化学的/生理学的作用

BAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1cat & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1cat & 50 nM wt hKRAS).

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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