SML2848

Nintedanib

≥98% (HPLC)

• Synonym(s): (3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester, (Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}phenylamino)methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, BIBF 1120, BIBF-1120, BIBF1120, Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
• Empirical Formula (Hill Notation): C₃₁H₃₃N₅O₄
• CAS Number: 656247-17-5
• Molecular Weight: 539.62
• MDL番号: MFCD11974012

Properties

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES string: O=C(NC1=C2)/C(C1=CC=C2C(OC)=O)=C(C3=CC=CC=C3)\NC4=CC=C(C=C4)N(C(CN5CCN(CC5)C)=O)C

Description

生物化学的／生理学的作用

Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC₅₀ = 34/21/13 nM), FGFR-1/2/3/4 (IC₅₀ = 69/37/108/610 nM), PDGFRα/β (IC₅₀ = 59/65 nM), as well as Flt-3, Lck, Lyn, and Src (IC₅₀ = 26, 16, 195, 156 nM, repectively), but not 33 other kinases. Nintedanib exhibits antiangiogenic and antifibrotic efficacy in cultures and in animal models of cancers and pulmonary fibrosis in vivo.

Safety Information

• ピクトグラム: GHS05,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301 - H315 - H318 - H361fd - H372
• 注意書き: P201 - P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 1
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable