- SML2904
All Photos(1)
SML2904
AGF347
≥98% (HPLC)
All Photos(1)
Synonym(s):
(4-(4-(2-Amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl)-2-fluorobenzoyl)-L-glutamic acid, (S)-2-(4-(4-(2-Amino-4-oxo-3H-pyrrolo[3,2-d]pyrimidin-5(4H)-yl)butyl)-2-fluorobenzamido)pentanedioic acid, N-[4-[4-(2-Amino-3,4-dihydro-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl]-L-glutamic acid
Empirical Formula (Hill Notation):
C22H24FN5O6
Molecular Weight:
473.45
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品質水準
アッセイ
≥98% (HPLC)
形状
powder
色
white to beige
溶解性
DMSO: 2 mg/L, clear
保管温度
2-8°C
SMILES string
O=C(CC[C@H](NC(C1=CC=C(C=C1F)CCCCN2C=CC(N=C(N3)N)=C2C3=O)=O)C(O)=O)O
Compare Similar Items
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This Item | A1487 | SAB4301878 | SAB2108508 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - | assay - |
| form powder | form powder | form buffered aqueous glycerol solution | form buffered aqueous solution |
| color white to beige | color off-white to brown | color - | color - |
| solubility DMSO: 2 mg/L, clear | solubility DMSO: >9 mg/mL (warmed) | solubility - | solubility - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
生物化学的／生理学的作用
AGF347 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) that inhibits mitochondrial C1 metabolism. It also inhibits cytosolic C1 targets such as SHMT1, GARFTase, and AICARFTase. AGF347 inhibits de novo purine biosynthesis. AGF347 exhibits potent broad spectrum in vitro and in vivo antitumor efficacy.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
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