SML2961

GRL-0617

≥98% (HPLC)

• Synonym(s): 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide, GRL 0617, GRL0617
• Empirical Formula (Hill Notation): C₂₀H₂₀N₂O
• CAS Number: 1093070-16-6
• Molecular Weight: 304.39
• MDL番号: MFCD12547683

Properties

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D -72.0 to -82.0°, c = 0.5 in chloroform-d
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• InChI: 1S/C20H20N2O/c1-14-9-10-17(21)13-19(14)20(23)22-12-11-16-7-4-6-15-5-2-3-8-18(15)16/h2-10,13H,11-12,21H2,1H3,(H,22,23)
• InChI key: SVHZQKLXYGYSMU-UHFFFAOYSA-N

Description

生物化学的／生理学的作用

GRL-0617 is a cell penetrant non-cytotoxic and potent inhibitor of the SARS-CoV -2 papain-like protease (SCoV2-PLpro) and SCoV-PLpro. GRL-0617 reversibly binds to SCoV2-PLpro and disrupts its interaction with Interferon-stimulated gene 15 (ISG15). GRL-0617 poorly affects (> 100 μM) the activities of MERS PLpro, a series of cysteine proteases, including the human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3, and a papain-like protease (PLP2) from the human coronavirus NL63. GRL-0617 suppress SARS-CoV-2 infection and promote anti-viral immunity.

Safety Information

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable