Merck
  • SML2974
All Photos(1)

SML2974

Sigma-Aldrich

Apilimod

≥98% (HPLC)

All Photos(1)
Synonym(s):
3-Methyl-benzaldehyde 2-[6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]hydrazone, STA 5326, STA-5326
Empirical Formula (Hill Notation):
C23H26N6O2
CAS Number:
541550-19-0
Molecular Weight:
418.49
MDL番号:
MFCD09954108

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

色

white to beige

溶解性

DMSO: 2 mg/mL, clear

保管温度

−20°C

InChI

1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+

InChI key

HSKAZIJJKRAJAV-KOEQRZSOSA-N

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Apilimod ≥98% (HPLC)

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SML2974

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SMB00702

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Apicidin ≥98% (HPLC), from microbial

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Apixaban ≥98% (HPLC)

Sigma-Aldrich

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Apixaban

assay

≥98% (HPLC)

assay

≥97% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

solid

form

powder

color

white to beige

color

-

color

-

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 27 mg/mL, 1 M KOH: 50 mg/mL

solubility

DMSO: ~1 mg/mL

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

生物化学的／生理学的作用

Apilimod (STA-5326) is a potent, orally active and selective inhibitor of the cytokines IL-12 and IL-23. Apilimod selectively suppresses synthesis of IL-12 and IL-23 by inhibition of phosphotransferase activity of TLR-4 regulator lipid kinase PIKfyve (phosphatidylinositol-3-phosphate 5-kinase). It suppresses Th1 cells response in vivo and reduces inflammatory histopathologic changes. Also, it exhibits strong anti COVID-19 activity in two cell lines (Vero E6:IC50 < 0.08 μM; A549-ACE2:IC50 = 0.007 μM). Apilimod potently reduces entry of SARS-CoV S pseudovirions on 293/hACE2 cells.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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