Merck
  • SML3163
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SML3163

Sigma-Aldrich

Mpro inhibitor 5h

≥98% (HPLC)

Synonym(s):
Mpro inhibitor 5h, 1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-2-(2-Benzothiazolyl)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]ethyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-1H-indole-2-carboxamide
Empirical Formula (Hill Notation):
C30H33N5O5S
Molecular Weight:
575.68

品質水準

アッセイ

≥98% (HPLC)

形状

powder

white to beige

溶解性

DMSO: 2 mg/mL, clear

保管温度

2-8°C

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Sigma-Aldrich

Sigma-Aldrich

SML3163

Mpro inhibitor 5h

Supelco

Supelco

SQC017

PAH、HPLC

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

-

form

solid

form

powder

color

white to beige

color

-

color

yellow

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 25 mg/mL, water: 50 mg/mL

solubility

H2O: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

100

生物化学的/生理学的作用

Mpro inhibitor 5h is a potent and selective tight-binding reversible inhibitor of SARS-CoV-2 Mpro that blocks virus replication. It protects VeroE6 cells form SARS-CoV-2WK-521 infection. Mpro inhibitor 5h works synergistically with remdesivir against SARS-CoV-2. Mpro inhibitor 5h shows no significant cytotoxicity to several cell lines at 200 μM.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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