- SML3285
All Photos(1)
SML3285
Apixaban
≥98% (HPLC)
All Photos(1)
Synonym(s):
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247, BMS562247
Empirical Formula (Hill Notation):
C25H25N5O4
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This Item | A-191 | SML2974 | A8851 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form - | form powder | form solid |
| color white to beige | color - | color white to beige | color - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility DMSO: 2 mg/mL, clear | solubility DMSO: ~1 mg/mL |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level 200 |
生物化学的／生理学的作用
Apixaban is an orally active, active site-targeting, highly potent and selective factor Xa (FXa) inhibitor (human/rabbit Ki = 0.08/0.17 nM; trypsin Ki >3 μM) with good anticoagulant activity in vitro (EC2x = 3.8 μM by prothrombin time (PT) assay, 5.1 μM by activated partial thromboplastin time (aPTT) assay) and antithrombotic efficacy in vivo (IC50 = 329 nM i.v. by rabbit arteriovenous shunt model).
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
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