SML3313

PF-07321332

≥95% (HPLC)

• Synonym(s): Nirmatrelvir, (1R,2S,5S)-N-[(1S)-1-Cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• Empirical Formula (Hill Notation): C₂₃H₃₂F₃N₅O₄
• CAS Number: 2628280-40-8
• Molecular Weight: 499.53

Properties

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES string: O=C(N[C@H](C#N)C[C@@]1(CCNC1=O)[H])[C@H]2N(C[C@]3([C@@]2(C3(C)C)[H])[H])C([C@@H](NC(C(F)(F)F)=O)C(C)(C)C)=O

Description

生物化学的／生理学的作用

Nirmatrelvir is a high efficacy oral antiviral that is active against COVID-19 variants, including omicron. PF-07321332 covalently and reversibly binds to the cysteine 145 residue of the viral 3CLpro (SARS-CoV-2 main protease) catalytic domain to inhibit the SARS-CoV-2 replication cycle ( IC50 ~ 4 nM). Nirmatrelvir poorly affects cathepsin-K (IC50 = 231 nM) with no inhibition towards caspases.

Safety Information

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable