SML3389

Vilanterol trifenatate

≥95% (HPLC)

• Synonym(s): 4-[(1R)-2-({6-[(2-{[(2,6-Dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol, triphenylacetate salt, GW 642444 trifenatate, GW 642444M, GW-642444 trifenatate, GW-642444M, GW642444 trifenatate, GW642444M, Vilanterol triphenylacetate sal
• Empirical Formula (Hill Notation): C₂₄H₃₃Cl₂NO₅·C₂₀H₁₆O₂
• CAS Number: 503070-58-4
• Molecular Weight: 774.77
• MDL番号: MFCD21362970

Properties

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES string: OC(C(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O.ClC(C=CC=C4Cl)=C4COCCOCCCCCCNC[C@@H](C5=CC(CO)=C(C=C5)O)O
• InChI: 1S/C24H33Cl2NO5.C20H16O2/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28;21-19(22)20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h5-9,14,24,27-30H,1-4,10-13,15-17H2;1-15H,(H,21,22)/t24-;/m0./s1
• InChI key: KLOLZALDXGTNQE-JIDHJSLPSA-N

Description

生物化学的／生理学的作用

Vilanterol is a potent and selective, beta2 (β2)-adrenoceptor agonist that stimulates cellular cAMP accumulation in CHO cells expressing human beta2, but not beta1 or beta3, adrenoceptor (pEC50 = 9.4/β2, 6.4/β1, 6.1/β3). Vilanterol inhibits the contraction of electrically stimulated guinea pig trachea strips and displays in vivo therapeutic efficacy in a guinea pig asthma model of histamine-induced bronchospasm (EC90 = nebulizer concentration 30 μM).

Safety Information

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable