R-spondin1 is essential in sex determination, skin differentiation and malignancy.
Parma P, et al.
Nature Genetics, 38, 1304-1309 (2006)
R-Spondin proteins: a novel link to beta-catenin activation.
Kim KA, et al.
Cell Cycle, 5, 23-26 (2006)
Xuefeng Gu et al.
Oncotarget, 6(12), 9756-9765 (2015-04-14)
Although radiation therapy is the most effective postoperative adjuvant treatment, it does not substantially improve the long-term outcomes of glioma patients because of the characteristic radioresistance of glioma. We found that R-Spondin1 (Rspo1) expression was elevated in high-grade gliomas and...
Minke E Binnerts et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(37), 14700-14705 (2007-09-07)
The R-Spondin (RSpo) family of secreted proteins act as potent activators of the Wnt/beta-catenin signaling pathway. We have previously shown that RSpo proteins can induce proliferative effects on the gastrointestinal epithelium in mice. Here we provide a mechanism whereby RSpo1...
Yong-Guo Zhang et al.
Autophagy, 15(11), 1935-1953 (2019-03-22)
Extracellular HMGB1 (high mobility group box 1) is considered as a damage-associated molecular pattern protein. However, little is known about its intracellular role. We studied the mechanism whereby intestinal epithelial HMGB1 contributes to host defense, using cell culture, colonoids, conditional...