WH0007157M1

Sigma-Aldrich

Monoclonal Anti-TP53 antibody produced in mouse

clone 2C3, purified immunoglobulin, buffered aqueous solution

別名:
抗TRP53抗体, 抗p53抗体, 抗LFS1抗体
MDL番号:
NACRES:
NA.41

品質水準

100

由来生物

mouse

抗体製品の状態

purified immunoglobulin

antibody product type

primary antibodies

クローン

2C3, monoclonal

形態

buffered aqueous solution

species reactivity

human

アプリケーション

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

アイソタイプ

IgG1κ

結合体

unconjugated

GenBank® accession no.

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... TP53(7157)

詳細

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

免疫原

TP53 (AAH03596, 94 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNL

生物化学的/生理学的作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

物理的形状

Solution in phosphate buffered saline, pH 7.4

法的情報

GenBank is a registered trademark of United States Department of Health and Human Services

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

試験成績書(COA)

原産地証明書(COO)

Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
Hong Chang, et.al
British Journal of Haematology, 127(3), 280-284 (2004)
Cooper GM
The Cell: A Molecular Approach (2000)
Cell Cycle and Apoptosis
Bruna Pucci, et.al
Neoplasia, 2(4), 291-299 (2000)
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4), 291-299 (2000)
Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions.
Chang H
British Journal of Haematology, 127(3), 280-284 (2004)
資料
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
さらに詳しく
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
さらに詳しく

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