Avanti Research™, A Croda Brand

Adjuvants in Immunotherapy & Vaccine Development

Vaccine adjuvants using heterogeneous monophosphoryl Lipid A (MPL) derived from Salmonella minnesota R595 have proven to be safe and effective at inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines. The Avanti Research™ team revolutionized immunotherapy and vaccine development with the introduction of synthetic MPL derivatives and adjuvant systems. We offer multiple Avanti Research™ synthetic analogs of MPL containing a single molecular species that have been shown to be effective and safe at inducing an immune response as their natural product predecessor. PHAD™, 3D-PHAD™, and 3D(6A)-PHAD™ have been tested extensively in animals using a variety of antigens. In all cases, these adjuvants exhibit a similar activity and safety profile to bacterially-derived MPL.

UltimateSPLASH™ ONE

UltimateSPLASH™ ONE is the complete internal standard solution for quantitative lipidomics. It consists of one vial containing 69 high-purity deuterium-labeled internal standards covering 15 lipid classes. Each vial contains 1.2 ml of 1:1 DCM:MeOH solution that has been meticulously characterized, quantitated, and blended for accurate quantitation using multiple lipidomics techniques.

LIPID MAPS^® Mass Spec Standards

Avanti Research™ is the exclusive licensed manufacturer and supplier of LIPID MAPS^® Mass Spec Standards for lipid analysis, including glycerolipids, glycerophopholipids, sphingolipids, and sterols. Quantitative standards are used to identify the structure or concentration of molecular species in mass spectrometry. Qualitative standards are used to tag DNA polymerase for the general identification of lipids by mass spectrometry analysis. Whatever your application, Avanti Research™ chemically pure synthetic lipid standards are characterized and prepackaged in unit containers at defined concentrations. A detailed certificate of analysis accompanies each standard.

Equipment

The Avanti Research™ Mini Extruder allows you to prepare large, unilamellar vesicles by extrusion in an efficient manner. Generate uniform populations of unilamellar liposomes without the use of solvents or detergents. Vesicle size is controlled by polycarbonate membrane selection. The particle size distribution of unilamellar vesicles prepared by extrusion is a function of the number of passes through the extruder membrane. Placing the stabilizer block-extruder assembly on a hot plate achieves rapid temperature control for lipids that have transition temperatures above room temperature. The special design, constructed of stainless steel and Teflon, allows for rapid cleaning of all wetted parts, reducing “down-time” between production of vesicles from different lipid species.

Dr. Anne Bendt - LipidMaps Podcast