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Andrea Kühnl et al.
Blood, 125(19), 2985-2994 (2015-03-26)
The gene CXXC5 on 5q31 is frequently deleted in acute myeloid leukemia (AML) with del(5q), suggesting that inactivation of CXXC5 might play a role in leukemogenesis. Here, we investigated the functional and prognostic implications of CXXC5 expression in AML. CXXC5...
Jessica L Forbester et al.
Infection and immunity, 83(7), 2926-2934 (2015-05-13)
The intestinal mucosa forms the first line of defense against infections mediated by enteric pathogens such as salmonellae. Here we exploited intestinal "organoids" (iHOs) generated from human induced pluripotent stem cells (hIPSCs) to explore the interaction of Salmonella enterica serovar...
Linda J W Bosch et al.
Oncotarget, 8(38), 63140-63154 (2017-10-04)
Diversity in colorectal cancer biology is associated with variable responses to standard chemotherapy. We aimed to identify and validate DNA hypermethylated genes as predictive biomarkers for irinotecan treatment of metastatic CRC patients. Candidate genes were selected from 389 genes involved...
Katarzyna Lubecka et al.
International journal of molecular sciences, 19(12) (2018-12-14)
An epigenetic component, especially aberrant DNA methylation pattern, has been shown to be frequently involved in sporadic breast cancer development. A growing body of literature demonstrates that combination of agents, i.e. nucleoside analogues with dietary phytochemicals, may provide enhanced therapeutic...
Ying Wang et al.
Oncology letters, 9(6), 2449-2454 (2015-07-03)
The present study aimed to investigate whether artesunate (ART) could enhance the rate of apoptosis induced by decitabine (DAC) in the high-risk myelodysplastic syndrome (MDS) SKM-1 cell line, and examine the potential underlying mechanisms. The cytotoxicity and effect upon the...
Thomas Schroeder et al.
Annals of hematology, 97(2), 335-342 (2017-11-21)
In contrast to the evidence regarding azacitidine (Aza), there is limited knowledge about the combination of decitabine (DAC) and donor lymphocyte infusions as salvage therapy for relapse after allogeneic stem cell transplantation (allo-SCT) so far. We retrospectively analyzed data of...
Daizong Ji et al.
Biosensors & bioelectronics, 129, 216-223 (2018-10-10)
Parkinson's disease caused by lack of dopamine in brain is a common neurodegenerative disorder. The traditional treatment is to replenish levodopa since it could pass through blood brain barrier and form dopamine. However, its accumulation can cause patients' movement disorders...
Satoshi Imanishi et al.
Oncotarget, 8(41), 69906-69915 (2017-10-21)
Previous studies showed that downregulation of pyrimidine salvage underlies resistance against 5-azacytidine (AZA), indicating an important role for
Tingting Chen et al.
Polymers, 11(12) (2019-11-30)
The poly(acryloyloxyethyl trimethyl ammonium chloride-co-acrylamide), P(DAC-AM), is a kind of cationic polyelectrolyte usually applied in a solution form, and its performance is affected by its structure and the environment where it is used. In particular, its viscosity properties in salt...
N S D Larmonie et al.
Oncogene, 37(1), 107-115 (2017-09-12)
In acute myeloid leukemia (AML), specific genomic aberrations induce aberrant methylation, thus directly influencing the transcriptional programing of leukemic cells. Therefore, therapies targeting epigenetic processes are advocated as a promising therapeutic tool for AML treatment. However, to develop new therapies...
Jungil Choi et al.
Applied microbiology and biotechnology, 100(5), 2355-2365 (2016-01-13)
Tuberculosis (TB) is a major global health problem, and multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are spreading throughout the world. However, conventional drug susceptibility test (DST) methods, which rely on the detection of the colony formation on a...
Maria Cristina Petralia et al.
Pharmaceuticals (Basel, Switzerland), 12(4) (2019-12-01)
The emerging role of epigenetics in the pathogenesis of autoimmune diseases has recently attracted much interest on the possible use of epigenetic modulators for the prevention and treatment of these diseases. In particular, we and others have shown that drugs...
Gordana Wutz et al.
The EMBO journal, 36(24), 3573-3599 (2017-12-09)
Mammalian genomes are spatially organized into compartments, topologically associating domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. How compartments, TADs, and loops are generated is unknown. It has been proposed that cohesin forms TADs and loops...
Y-Q Li et al.
Cell death & disease, 6, e1618-e1618 (2015-01-23)
Our previous microarray analysis indicated that miR-34c was downregulated in nasopharyngeal carcinoma (NPC). However, little is known about the function and molecular mechanism of miR-34c in NPC. In this study, miR-34c was found to be significantly downregulated in NPC cell...
Yin Zhao et al.
Cells, 9(3) (2020-03-04)
Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC....
Christoph Bruser et al.
IEEE transactions on biomedical circuits and systems, 9(3), 421-430 (2014-09-10)
Unobtrusive, long-term monitoring of cardiac (and respiratory) rhythms using only non-invasive vibration sensors mounted in beds promises to unlock new applications in home and low acuity monitoring. This paper presents a novel concept for such a system based on an...
Guocheng Zhong et al.
International journal of medical sciences, 17(15), 2346-2356 (2020-09-15)
Background: Acute myeloid leukemia (AML) is a malignant hematological disease with high refractory rate. Immune escape of AML cells is one of the underlying mechanisms mediating the relapse of the cancers. Various immunotherapies based on the 'patients' immune response to...
Weiyang Tang et al.
Analytical and bioanalytical chemistry, 410(28), 7325-7336 (2018-09-21)
Fatty acid/alcohol-based hydrophobic deep eutectic solvents (DESs) have been considered to be eco-friendly alternatives to replace conventional hydrophobic organic solvents (i.e., halogenated solvents). These novel eco-friendly solvents are applied in the extraction and determination of two antibiotics (levofloxacin, LOF; ciprofloxacin...
Xinjiang Zhu et al.
Oncology reports, 33(5), 2567-2574 (2015-03-05)
The present study aimed to identify novel histone modification markers in gastric cancer (GC) by chromatin immunoprecipitation microarray (ChIP-chip) analysis and to determine whether these markers were able to discriminate between normal and GC cells. We also tested for correlations...
Mu Naushad et al.
Environmental science and pollution research international, 22(20), 15853-15865 (2015-06-05)
Activated carbon was prepared from date pits via chemical activation with H3PO4. The effects of activating agent concentration and activation temperature on the yield and surface area were studied. The optimal activated carbon was prepared at 450 °C using 55...
Jonathan David Blutinger et al.
Food research international (Ottawa, Ont.), 120, 196-208 (2019-04-20)
Selective laser broiling is a novel food processing technique that utilizes a 2-axis mirror galvanometer system to direct laser power to cook raw food. Unlike conventional cooking processes, laser cooking benefits from the high spatial and temporal precision of power...
Jun Wang et al.
Journal of molecular medicine (Berlin, Germany), 92(12), 1257-1269 (2014-07-06)
Pancreatic cancer (PaC) is the fifth leading cause of cancer death in the world, but the molecular mechanisms for its development remain unclear. Regenerating islet-derived protein 3-alpha (Reg3A) has been reported overexpressed in pancreatic inflammation and associated with PaC malignancies...
Zhaohui Xiong et al.
The Journal of pathology, 244(2), 164-175 (2017-10-22)
PAX9 is a transcription factor of the PAX family characterized by a DNA-binding paired domain. Previous studies have suggested a potential role of PAX9 in squamous cell differentiation and carcinogenesis of the oro-oesophageal epithelium. However, its functional roles in differentiation...
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production...
Chenji Wang et al.
Frontiers in genetics, 9, 356-356 (2018-09-21)
DNA methylation-based biomarkers were suggested to be promising for early cancer diagnosis. However, DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC), especially in Chinese Han populations have not been identified and evaluated quantitatively. Candidate tumor suppressor genes (N =...
Alison E Casey et al.
The Journal of cell biology, 217(8), 2951-2974 (2018-06-21)
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete....
Munetaka Nakamura et al.
Journal of medical virology, 89(3), 508-517 (2016-07-20)
The present study investigated the effect of a DNA demethylating agent, decitabine, against Epstein-Barr virus-associated gastric cancer (EBVaGC). Decitabine inhibited cell growth and induced G2/M arrest and apoptosis in EBVaGC cell lines. The expression of E-cadherin was up-regulated and cell...
Bumjun Kim et al.
Molecular pharmaceutics, 16(5), 1813-1826 (2019-03-19)
The plasticity of cancer epigenetics makes them plausible candidates for therapeutic intervention. We took advantage of elevated expression of lysophosphatidic acid receptor 1 (LPAR1) in triple negative breast cancer (TNBC) tissues to target decitabine (DAC) and panobinostat (PAN) to breast...
Ola M Abdallah et al.
Luminescence : the journal of biological and chemical luminescence, 33(6), 1094-1100 (2018-07-27)
A simple, highly sensitive and selective spectrofluorimetric method has been developed and fully validated for the determination of daclatasvir (DAC) and ledipasvir (LED) in tablets and human plasma. The method is based on measurement of the native fluorescence in methanol...
Hongxing Shen et al.
Journal of cellular biochemistry, 116(8), 1563-1573 (2015-02-05)
The dysregulation of microRNAs (miRNAs) contributes to the pathogenesis of human malignancies, and miRNA expression can be affected by genetic and epigenetic changes, such as methylation of the CpG islands of their promoters. To identify miRNAs regulated by DNA methylation...
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