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Aimei Liu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 132, 110661-110661 (2019-07-07)
Currently, T-2 toxin has been reported to cause liver toxicity with the effects of oxidative stress and inflammation; however, the underlying mechanism of T-2 toxin-induced liver injury is not fully understood. Increasing lines of evidence show that DNA methylation affects
Dominik Wyser et al.
Neurophotonics, 4(4), 041413-041413 (2017-08-26)
With the aim of transitioning functional near-infrared spectroscopy (fNIRS) technology from the laboratory environment to everyday applications, the field has seen a recent push toward the development of wearable/miniaturized, multiwavelength, multidistance, and modular instruments. However, it is challenging to unite
Shasha Su et al.
PloS one, 10(11), e0143513-e0143513 (2015-11-26)
Leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) is a candidate marker for colorectal cancer stem cells (CSC). In the current study, we investigated the methylation status within thelgr5 promoter and evaluated its relationship with CSC differentiation, prognosis for colorectal cancer, and its
Monika Muchová et al.
Materials science & engineering. C, Materials for biological applications, 116, 111242-111242 (2020-08-19)
2,3-Dialdehyde cellulose (DAC) was used as an efficient and low-toxicity crosslinker to prepare thin PVA/DAC hydrogel films designed for topical applications such as drug-loaded patches, wound dressings or cosmetic products. An optimization of hydrogel properties was achieved by the variation
Hooseok Lee et al.
PloS one, 12(10), e0187108-e0187108 (2017-11-01)
We describe a wearable sensor developed for cardiac rehabilitation (CR) exercise. To effectively guide CR exercise, the dedicated CR wearable sensor (DCRW) automatically recommends the exercise intensity to the patient by comparing heart rate (HR) measured in real time with
Hongxing Shen et al.
Journal of cellular biochemistry, 116(8), 1563-1573 (2015-02-05)
The dysregulation of microRNAs (miRNAs) contributes to the pathogenesis of human malignancies, and miRNA expression can be affected by genetic and epigenetic changes, such as methylation of the CpG islands of their promoters. To identify miRNAs regulated by DNA methylation
Chloe Chong et al.
Nature communications, 11(1), 1293-1293 (2020-03-12)
Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of mediating T cell-based tumor rejection still face important challenges. Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune responses.
Yong-Gyun Jung et al.
Scientific reports, 8(1), 8651-8651 (2018-06-07)
The Disc Agarose Channel (DAC) system utilizes microfluidics and imaging technologies and is fully automated and capable of tracking single cell growth to produce Mycobacterium tuberculosis (MTB) drug susceptibility testing (DST) results within 3~7 days. In particular, this system can
Mika Hosokawa et al.
Biological & pharmaceutical bulletin, 40(12), 2199-2204 (2017-09-29)
Limited information is currently available on how to apply epigenetic modifiers to current colorectal cancer (CRC) chemotherapy. The purpose of this study is to clarify the schedule-dependent effects of combined treatment with conventional anticancer drugs and epigenetic modifiers in human
Shota Tanaka et al.
Biological & pharmaceutical bulletin, 38(9), 1272-1279 (2015-07-17)
The effects of decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, on metastasis and exosomal expression of microRNAs were examined in SW620/OxR cells, a human colorectal cancer (CRC) cell line (SW620) with acquired resistance to oxaliplatin. This cell line shows an
Alice Pasini et al.
Biochimica et biophysica acta. Gene regulatory mechanisms, 1861(5), 463-472 (2018-03-21)
Cyclooxygenase-2 (COX-2), with its main antifibrotic metabolite PGE2, is regarded as an antifibrotic gene. Repressed COX-2 expression and deficient PGE2 have been shown to contribute to the activation of lung fibroblasts and excessive deposition of collagen in pulmonary fibrosis. We
Ola M Abdallah et al.
Luminescence : the journal of biological and chemical luminescence, 33(6), 1094-1100 (2018-07-27)
A simple, highly sensitive and selective spectrofluorimetric method has been developed and fully validated for the determination of daclatasvir (DAC) and ledipasvir (LED) in tablets and human plasma. The method is based on measurement of the native fluorescence in methanol
Verena Schadewaldt et al.
PloS one, 14(4), e0215153-e0215153 (2019-04-10)
The organisational context of healthcare settings has an essential role in how research evidence is used in clinical practice. The Alberta Context Tool (ACT) measures 10 concepts of organisational context with higher scores indicating a more positive work environment and
Jessica Dittmann et al.
Molecular carcinogenesis, 56(6), 1578-1589 (2017-01-07)
Progression from human papillomavirus-induced premalignant cervical intraepithelial neoplasia (CIN) to cervical cancer (CC) is driven by genetic and epigenetic events. Our microarray-based expression study has previously shown that inter-α-trypsin-inhibitor heavy chain 5 (ITIH5) mRNA levels in CCs were significantly lower
Xuexiao Wang et al.
Oncotarget, 8(12), 19661-19673 (2017-02-06)
Bridging integrator-1 (Bin1), as a tumor suppressor, is frequently attenuated or even abolished in multiple primary cancers. A reduced expression of Bin1 caused by DNA methylation, has been reported in breast and prostate cancers. However, the methylation status of Bin1
Dong-Xu He et al.
Journal of pharmaceutical and biomedical analysis, 102, 500-508 (2014-12-03)
Although chemotherapy is widely used to treat human cancers, most chemotherapeutic agents only benefit a small fraction of patients because of the heterogeneity of cancers. Therefore, identifying of the sensitivity of cancers toward various chemotherapies would be important for choosing
Xiaoting Gu et al.
European journal of pharmacology, 792, 7-14 (2016-11-05)
The global gene expression and DNA methylation of genes in adriamycin-resistant human breast cancer cells (MCF-7/ADM cells) are similar to those in paclitaxel-resistant MCF-7 cells (MCF-7/PTX) and are significantly different from those in wild-type MCF-7 cells. DNA methylation is associated
Janaina de Cássia Orlandi Sardi et al.
Journal of medical microbiology, 66(6), 816-824 (2017-06-10)
Staphylococcus aureus infections have contributed to the global healthcare burden, particularly with regard to hospital-acquired meticillin-resistant S. aureus (MRSA) infections. This study describes the antibacterial activity of diacetylcurcumin (DAC) against meticillin-susceptible S. aureus/MRSA biofilm formation, survival, metabolic activity and structure;
Xiaomin Chen et al.
Experimental and therapeutic medicine, 17(1), 205-213 (2019-01-18)
Cyclin dependent kinase inhibitor 2B (CDKN2B) encodes a cyclin-dependent kinase inhibitor that may enhance the formation of atherosclerotic plaques. The aim of the present study was to investigate the contribution of CDKN2B promoter methylation on the risk of coronary heart
Shuang Zhao et al.
Anti-cancer agents in medicinal chemistry, 19(6), 772-782 (2019-02-05)
DNA methylation, which acts as an expression regulator for multiple Tumor Suppressor Genes (TSGs), is believed to play an important role in Nasopharyngeal Carcinoma (NPC) development. We compared the effects of 5-aza-2-deoxycytidine (decitabine, DAC) on gene expression using RNA sequencing
Hongxia Li et al.
Clinical epigenetics, 10(1), 137-137 (2018-11-08)
The role of TMEM176A in human hepatocellular carcinoma (HCC) is unknown. This study explored the epigenetic regulation and function of TMEM176A in human HCC. Twelve HCC cell lines and 126 cases of primary cancer were analyzed. Methylation-specific PCR, immunohistochemistry, flow
Sonia Abou Najem et al.
Cells, 8(12) (2019-11-27)
Atypical epigenetic processes including histone acetylation and DNA methylation have been identified as a fundamental theme in hematologic malignancies. Such mechanisms modify gene expression and prompt, in part at least, the initiation and progression of several malignancies including acute myeloid
Simon Grelet et al.
The Journal of pathology, 237(1), 25-37 (2015-04-24)
We have explored the role of the human NANOS3 gene in lung tumour progression. We show that NANOS3 is over-expressed by invasive lung cancer cells and is a prognostic marker for non-small cell lung carcinomas (NSCLCs). NANOS3 gene expression is
Hui Yang et al.
Leukemia research, 59, 85-92 (2017-06-10)
FF-10501-01 is a selective inosine monophosphate dehydrogenase (IMPDH) inhibitor that has shown activity in cancer cell lines. We studied whether FF-10501-01 is effective in targeting a variety of hypomethylating agent (HMA)-sensitive and -resistant acute myelogenous leukemia (AML) cell lines. We
Olga Kiseļova et al.
Medicina (Kaunas, Lithuania), 56(1) (2020-01-16)
Even though many industrially manufactured medicines are available, extemporaneous preparations still have their niche in dermatology. In several countries, dermatovenerologists are one of the specialists prescribing extemporaneous medicines the most. In order to increase the quality of compounded medications and
Hui Chen et al.
Oncotarget, 6(24), 20449-20465 (2015-06-04)
Axon guidance protein Semaphorin 3E (Sema3E) promotes tumor metastasis and suppresses tumor cell death. Here, we demonstrated that Sema3E was decreased in gastric cancer. Its levels were inversely associated with tumor progression. Levels of Sema3E were associated with low p300
Ruipan Zheng et al.
Clinical epigenetics, 9, 50-50 (2017-05-12)
To explore the epigenetic changes and function of
Dong Wang et al.
Oncotarget, 8(49), 86325-86338 (2017-11-22)
Pheochromocytoma (PCC) is related to germline mutations in 12 susceptibility genes. Although comparative genomic hybridization array has revealed some putative tumor suppressor genes on the short arm of chromosome 1 that are likely to be involved in PCC tumorigenesis, the
Jaehyouk Lee et al.
PloS one, 11(11), e0166664-e0166664 (2016-11-12)
Epigenetic aberrations play crucial roles in prostate cancer (PCa) development and progression. The DEFB1 gene, which encodes human ß-defensin-1 (HBD-1), contributes to innate immune responses and functions as a potential tumor suppressor in urological cancers. We investigated whether differential DNA
Carolina Makowski et al.
Hippocampus, 30(10), 1058-1072 (2020-06-03)
Hippocampal circuitry has been posited to be fundamental to positive symptoms in psychosis, but its contributions to other factors important for outcome remains unclear. We hypothesized that longitudinal changes in the hippocampal circuit and concomitant changes of intracortical microstructure are
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