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Yan-Xia An et al.
Bioresource technology, 192, 165-171 (2015-06-01)
Pretreatment of lignocelluloses is a key step in the biorefinery for production of biofuels and valuable platform chemicals. In this work, various lignocelluloses were pretreated using cholinium ionic liquids (ILs) that are wholly composed of biomaterials, and fractionated into carbohydrate-rich...
Nicholas J Saner et al.
The Journal of physiology, 598(8), 1523-1536 (2020-02-23)
Sleep restriction has previously been associated with the loss of muscle mass in both human and animal models. The rate of myofibrillar protein synthesis (MyoPS) is a key variable in regulating skeletal muscle mass and can be increased by performing...
M S Brook et al.
American journal of physiology. Endocrinology and metabolism, 313(6), E681-E689 (2017-08-16)
Current methods to quantify in vivo RNA dynamics are limited. Here, we developed a novel stable isotope (D
V Bjerre-Harpøth et al.
Journal of dairy science, 98(12), 8581-8596 (2015-10-12)
Our objective was to investigate the quantitative and qualitative effects of propylene glycol (PG) allocation on postpartum adipose tissue mobilization in over-conditioned Holstein cows. Nine ruminally cannulated and arterially catheterized cows were, at parturition, randomly assigned to a ruminal pulse...
Kristel Kodar et al.
Chembiochem : a European journal of chemical biology, 16(4), 683-693 (2015-02-04)
Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms through which these glycolipids exert their immunomodulatory potential. Recently, the macrophage-inducible C-type lectin...
Luca Mazzei et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(6), 1021-1037 (2015-07-25)
Helicobacter pylori (Hp) is a carcinogen that relies on Ni(II) to survive in the extreme pH conditions of the human guts. The regulation of genes coding for Ni(II) enzymes and proteins is effected by the nickel-responsive transcription factor NikR, composed...
Fabrizio Chiodo et al.
Carbohydrate research, 405, 102-109 (2015-01-13)
In order to re-build Man9GlcNAc2 clusters of the HIV gp120 glycoprotein, ∼2 nm gold glyconanoparticles (GNPs) were coated with the synthetic partial structures of Man9, the tetramannoside Manα1-2Manα1-2Manα1-3Manα1- and the pentamannoside Manα1-2Manα1-3[Manα1-2Manα1-6]Manα1-. Their interactions with the anti-HIV broadly neutralizing antibody...
Marie-Laurence Tremblay et al.
Scientific reports, 5, 11502-11502 (2015-06-27)
Spiders store spidroins in their silk glands as high concentration aqueous solutions, spinning these dopes into fibres with outstanding mechanical properties. Aciniform (or wrapping) silk is the toughest spider silk and is devoid of the short amino acid sequence motifs...
Gönül Yenilmez Çiftçi et al.
Journal of fluorescence, 25(6), 1819-1830 (2015-10-01)
In the present work, 3-[2-(diethylamino)ethyl]-7-oxy-4-methylcoumarin substituted cyclotriphosphazene (4) and cyclotetraphosphazene (5) derivatives were synthesized by the reactions of hexachlorocyclotriphosphazene (1) or octachlorocyclotetraphosphazene (2) with 3-[2-(diethylamino)ethyl]-7-hydroxy-4-methylcoumarin (3) for the first time. The quaternized cationic (6 and 7) and zwitterionic (8 and...
Joseph J Lee et al.
The American journal of clinical nutrition, 101(1), 34-43 (2014-12-21)
Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n-7 to 16:0 [SCD1₁₆] in plasma triacylglycerol FA has been used as an index to reflect liver SCD1₁₆...
Stephanie T Chung et al.
Diabetologia, 58(3), 596-603 (2014-12-03)
The role of increased gluconeogenesis as an important contributor to fasting hyperglycaemia at diabetes onset is not known. We evaluated the contribution of gluconeogenesis and glycogenolysis to fasting hyperglycaemia in newly diagnosed youths with type 2 diabetes following an overnight...
Nur Ashikin Abdul-Hamid et al.
Journal of food science, 80(11), H2603-H2611 (2015-10-13)
This study aimed to examine the variation in the metabolite profiles and nitric oxide (NO) inhibitory activity of Ajwa dates that were subjected to 2 drying treatments and different extraction solvents. (1)H NMR coupled with multivariate data analysis was employed....
Juan Li et al.
BMC gastroenterology, 14, 115-115 (2014-07-01)
Acute pancreatitis (AP) is a common inflammatory disease of the pancreas accompanied by serious metabolic disturbances. Nevertheless, the specific metabolic process of this disease is still unclear. Characterization of the metabolome may help identify biomarkers for AP. To identify potential...
Yasuhiro Shimada et al.
Carbohydrate research, 407, 10-15 (2015-02-24)
Poly-trans-[(2-carboxyethyl)germasesquioxane], Ge-132, is a water-soluble organic germanium compound with many reported physiological functions. The hydrolysate of Ge-132, 3-(trihydroxygermyl)propanoic acid, can interact with diol compounds; therefore, it can possibly interact with diol-containing sugar compounds, which have important physiological functions in sugar...
Joseph O Varghese et al.
Advanced materials (Deerfield Beach, Fla.), 27(17), 2734-2740 (2015-03-20)
Adsorbed molecules can significantly affect the properties of atomically thin materials. Physisorbed water plays a significant role in altering the optoelectronic properties of single-layer MoS2 , one such 2D film. Here the distinct quenching effect of adsorbed water on the...
Michael S Bono et al.
PloS one, 10(8), e0134846-e0134846 (2015-08-13)
In this study, we cultured Chlorella vulgaris cells with a range of lipid contents, induced via nitrogen starvation, and characterized them via flow cytometry, with BODIPY 505/515 as a fluorescent lipid label, and liquid-state 1H NMR spectroscopy. In doing so...
Daryl B Wong et al.
The journal of physical chemistry. B, 117(2), 623-635 (2013-01-02)
The vibrational dynamics of the antisymmetric and symmetric stretching modes of very low concentration spatially isolated D(2)O molecules in the room temperature ionic liquid (RTIL) 1-butyl-3-methylimidazolium hexafluorophosphate (BmImPF(6)) were examined using two-dimensional infrared (2D IR) vibrational echo spectroscopy and infrared...
Garvita Gupta et al.
PloS one, 10(8), e0134823-e0134823 (2015-08-11)
Dengue genome encodes a two component protease complex (NS2B-NS3pro) essential for the viral maturation/infectivity, thus representing a key drug target. Previously, due to its "complete insolubility", the isolated NS3pro could not be experimentally studied and it remains elusive what structure...
Sami T Tuomivaara et al.
Carbohydrate research, 402, 56-66 (2014-12-17)
Xyloglucans are structurally complex plant cell wall polysaccharides that are involved in cell growth and expansion, energy metabolism, and signaling. Determining the structure-function relationships of xyloglucans would benefit from the availability of a comprehensive and structurally diverse collection of rigorously...
Franklin John et al.
Macromolecular bioscience, 15(4), 521-534 (2014-12-18)
5,6-Bis(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside the cells. In spite of the promising potential as an anticancer agent...
Jungeun Bae et al.
The AAPS journal, 17(6), 1357-1368 (2015-07-01)
A novel redox-responsive amphiphilic polymer was synthesized with bioreductive trimethyl-locked quinone propionic acid for a potential triggered drug delivery application. The aim of this study was to synthesize and characterize the redox-responsive amphiphilic block copolymer micelles containing pendant bioreductive quinone...
Leila R Hill et al.
Dalton transactions (Cambridge, England : 2003), 42(1), 67-70 (2012-10-31)
Binuclear lanthanide complexes consisting of two lanthanide binding domains in kinetically stable DO3A binding pockets linked by a 3-functionalized meta-xylyl bridge form stable 1:1 adducts with isophthalate and dinicotinate in water. The influence of buffer, pH and ligand structure on...
Pierluigi Caboni et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 27 Suppl 2, 4-12 (2014-10-07)
Physiological changes leading to parturition are not completely understood while clinical diagnosis of labour is still retrospective. Gas chromatography mass spectrometry (GC/MS) and nuclear magnetic resonance spectroscopy (NMR) represent two of the main analytical platforms used in clinical metabolomics. Metabolomics...
Naotaka Sekiyama et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(30), E4036-E4045 (2015-07-15)
The eIF4E-binding protein (4E-BP) is a phosphorylation-dependent regulator of protein synthesis. The nonphosphorylated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4G and the recruitment of the small ribosomal subunit. Signaling events stimulate serial phosphorylation...
Settimio Pacelli et al.
International journal of biological macromolecules, 72, 1335-1342 (2014-12-03)
In this work, a natural polysaccharide gellan gum (GG) has been modified with methacrylic groups (GG-MA) and combined with polyethylene glycol dimethacrylate (PEG-DMA) in order to create novel injectable hydrogels that can be easily delivered through a needle and photocross-linked...
Xiaodong She et al.
Journal of colloid and interface science, 445, 151-160 (2015-01-27)
Hollow mesoporous silica nanoparticles (HMSNs) are one of the most promising carriers for effective drug delivery due to their large surface area, high volume for drug loading and excellent biocompatibility. However, the non-ionic surfactant templated HMSNs often have a broad...
Dominique E Williams et al.
Chembiochem : a European journal of chemical biology, 16(10), 1474-1482 (2015-05-09)
With the goal of designing a lysosomal phospholipase mimic, we optimized experimental variables to enhance Ce(IV) -assisted hydrolysis of phosphatidylcholine (PC) liposomes. Our best result was obtained with the chelating agent bis-tris propane (BTP). Similar to the hydrolytic enzyme, Ce(IV)...
Xiu-Rong Zhang et al.
Drug development and industrial pharmacy, 41(6), 916-926 (2014-05-03)
Mitomycin C (MTC) was incorporated to a micelle system preparing from a polymer named deoxycholic acid chitosan-grafted poly(ethylene glycol) methyl ether (mPEG-CS-DA). mPEG-CS-DA was synthesized and characterized by (1)H nuclear magnetic resonance ((1)H-NMR) and Fourier transform infrared spectroscopy. mPEG-CS-DA formed...
Jinping Jia et al.
Molecules (Basel, Switzerland), 20(6), 10065-10081 (2015-06-04)
Forsythiae Fructus (FF), the dried fruit of Forsythia suspensa, has been widely used as a heat-clearing and detoxifying herbal medicine in China. Green FF (GF) and ripe FF (RF) are fruits of Forsythia suspensa at different maturity stages collected about...
Еlena А Santalova et al.
Lipids, 50(1), 57-69 (2014-12-17)
Nine new cerebrosides 1a-d, 2a, 2b, 3a-c were found in the extract of a Far-Eastern glass sponge Aulosaccus sp. (class Hexactinellida). These β-D-glucopyranosyl-(1 → 1)-ceramides contain sphingoid bases (2S,3S,4R,11Z)-2-aminoeicos-11-ene-1,3,4-triol (in 1a-d), (2S,3S,4R,13Z)-2-aminoeicos-13-ene-1,3,4-triol (in 2a, b) and (2S,3S,4R,13S*,14R*)-2-amino-13,14-methylene-eicosane-1,3,4-triol (in 3a-c), which...
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