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Chih-Chung Lin et al.
Journal of clinical medicine, 8(4) (2019-04-03)
The upregulation of heme oxygenase-1 (HO-1) by the carbon monoxide-releasing molecule (CORM)-2 may be mediated through the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases [Nox] and reactive oxygen species (ROS) generation, which could provide cytoprotection against various cellular injuries.
Eun Jin Lim et al.
Apoptosis : an international journal on programmed cell death, 20(8), 1087-1098 (2015-05-30)
Tunicamycin (TN), one of the endoplasmic reticulum stress inducers, has been reported to inhibit tumor cell growth and exhibit anticarcinogenic activity. However, the mechanism by which TN initiates apoptosis remains poorly understood. In the present study, we investigated the effect
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Keke Li et al.
Cancer cell international, 20, 36-36 (2020-02-06)
Melanoma is one of the most aggressive tumors with the remarkable characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted therapy and immunotherapy benefit advanced melanoma patient treatment, BRAFi (BRAF inhibitor) resistance and the lower response rates or severe
Jessica M Pastoriza et al.
Clinical & experimental metastasis, 35(7), 613-623 (2018-08-24)
Black race compared to white race is associated with more advanced stage and biologically aggressive breast cancer. Consequently, black patients are more frequently treated with neoadjuvant chemotherapy (NAC) than white patients. However, it is unclear how distant recurrence-free survival (DRFS)
Kangfeng Jiang et al.
International immunopharmacology, 64, 140-150 (2018-09-03)
Barbaloin is the major anthraquinone compound that is isolated from the leaf exudates of Aloe vera and is often used as a bittering agent in alcoholic beverages. Here, we investigated the potential protective role of barbaloin in a mouse model
Elisabeth Wigenstam et al.
Toxicology, 328, 40-47 (2014-12-17)
Chlorine (Cl2) causes tissue damage and a neutrophilic inflammatory response in the airways manifested by pronounced airway hyperreactivity (AHR). The importance of early anti-inflammatory treatment has previously been addressed. In the previous study, both high-dose and low-dose of dexamethasone (DEX)
Konrad A Szychowski et al.
Neurotoxicity research, 36(3), 503-514 (2019-06-05)
Throughout the lifetime of humans, the amount of stem cells and the rate of cell proliferation continue to decrease. Reactive oxygen species (ROS) are one among the many factors that promote stem cell aging. Both a decrease in the level
M Cecilia Caino et al.
The Journal of clinical investigation, 127(10), 3755-3769 (2017-09-12)
Tumors adapt to an unfavorable microenvironment by controlling the balance between cell proliferation and cell motility, but the regulators of this process are largely unknown. Here, we show that an alternatively spliced isoform of syntaphilin (SNPH), a cytoskeletal regulator of
Chia-Chi Liu et al.
BMC cancer, 19(1), 473-473 (2019-05-22)
There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sigma-2 receptor is frequently reported in
Masaharu Fujita et al.
Toxicology in vitro : an international journal published in association with BIBRA, 59, 161-178 (2019-04-20)
The Amino acid Derivative Reactivity Assay (ADRA) is an in chemico alternative to animal testing for skin sensitization potential, in which measurements of multi-constituent solutions were sometimes affected by co-elution with nucleophilic reagents. So, we established a means of using
Sahib Zada et al.
Oncology reports, 42(4), 1621-1630 (2019-07-20)
One million females are diagnosed worldwide every year with breast cancer, and the mortality rate of these patients remains high. Several treatments, including surgery, are available for breast cancer. β‑Lapachone (β‑Lap), a natural quinone compound, has been developed for cancer
Jiangying Shi et al.
Oncotarget, 8(43), 74582-74594 (2017-11-02)
The pro-inflammatory and anti-inflammatory maladjustment has been acknowledged as one of the chief causations of inflammatory diseases and even cancers. Previous studies showed that plant-derived polyphenolic compounds were the most potent anti-oxidant and anti-inflammatory agents among all natural compounds. The
Esmaeil Dehghan et al.
Nature communications, 8(1), 2223-2223 (2017-12-22)
Nuclear factor (erythroid-derived 2)-like 2 and its Caenorhabditis elegans ortholog, SKN-1, are transcription factors that have a pivotal role in the oxidative stress response, cellular homeostasis, and organismal lifespan. Similar to other defense systems, the NRF2-mediated stress response is compromised
Lei Du et al.
Cell biology and toxicology, 36(3), 243-260 (2019-11-27)
Inflammation reaction mediated by NLRP3 inflammasome and Nrf2-related oxidative stress are vital participants in the development of diabetic nephropathy (DN) and closely associated to kidney fibrosis. Nrf2, a known antioxidative transcription factor, has been reported to activate NLRP3 inflammasome through
Zheng Feng et al.
Journal of gynecologic oncology, 29(5), e65-e65 (2018-07-20)
To present the surgical outcomes of advanced epithelial ovarian cancer (AEOC) since the implementation of a personalized approach and to validate multiple predictive models for R0 resection. Personalized strategies included: 1) Non-invasive model: preoperative clinico-radiological assessment according to Suidan criteria
I Gañán-Gómez et al.
Annals of hematology, 94(3), 379-392 (2014-10-18)
Current frontline therapies have improved overall survival in acute promyelocytic leukemia (APL) patients to exceptional rates; however, relapse is still a problem among high-risk and old patients. Therefore, the development of better and safer therapies continues to be a goal
Jessica Fiori et al.
Journal of chromatography. A, 1562, 115-122 (2018-06-04)
Monomeric catechins are important compounds in green tea accounting for potential bioactivity against a wide range of diseases. Besides catechins, l-Theanine (γ-glutamylethylamide), a characteristic amino acid in tea leaves, has become a further focus of the phytochemical research for the
Susumu Ishiguro et al.
Integrative cancer therapies, 19, 1534735419900555-1534735419900555 (2020-02-06)
A colon cancer growth inhibitor partially purified from the isolated cell wall membrane fraction of Chlorella sorokiniana, here referred to as Chlorella membrane factor (CMF), was evaluated for its antitumor and immunomodulatory effects in cell culture and in a colon
Zhong-Jie Liu et al.
Oxidative medicine and cellular longevity, 2015, 683197-683197 (2015-07-15)
Hyperglycemia can inhibit expression of the 8-oxoG-DNA glycosylase (OGG1) which is one of the key repair enzymes for DNA oxidative damage. The effect of hyperglycemia on OGG1 expression in response to local anesthetics-induced DNA damage is unknown. This study was
Li Hu et al.
Neuroscience bulletin, 36(5), 475-492 (2020-04-04)
Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla (RVLM) have been implicated in stress-induced hypertension (SIH). Prorenin, a member of the brain renin-angiotensin system (RAS), can directly activate microglia. The present study aimed
Soo Ah Jeong et al.
Oncotarget, 6(25), 21173-21192 (2015-06-09)
The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9(11)-dien-C28-methyl ester (CDDO-Me) is considered a promising anti-tumorigenic compound. In this study, we show that treatment with CDDO-Me induces progressive endoplasmic reticulum (ER)-derived vacuolation in various breast cancer cells and ultimately kills these cells by
Gabriele Gut et al.
Science (New York, N.Y.), 361(6401) (2018-08-04)
Obtaining highly multiplexed protein measurements across multiple length scales has enormous potential for biomedicine. Here, we measured, by iterative indirect immunofluorescence imaging (4i), 40-plex protein readouts from biological samples at high-throughput from the millimeter to the nanometer scale. This approach
Yue Wang et al.
Molecular medicine reports, 19(3), 1654-1664 (2018-12-29)
Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to their serious side effects. To develop compounds with decreased side effects and improved anti‑cancer activity, two novel types of 1,4‑naphthoquinone derivatives, 2,3‑dihydro‑2,3‑epoxy‑2‑propylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (EPDMNQ) and
Chang-Nim Im et al.
Oncology reports, 34(2), 920-928 (2015-06-03)
More efficient isolation and identification of cancer stem cells (CSCs) would help in determining their fundamental roles in tumor biology. The classical tool for this purpose is anchorage-independent tumorsphere culture. We compared the effects of differently textured culture plates and
Tetsuya Miyamoto et al.
Biochimica et biophysica acta. Proteins and proteomics, 1868(9), 140461-140461 (2020-06-01)
d-Amino acids are physiologically important components of peptidoglycan in the bacterial cell wall, maintaining cell structure and aiding adaptation to environmental changes through peptidoglycan remodelling. Therefore, the biosynthesis of d-amino acids is essential for bacteria to adapt to different environmental
Jin-Xiu Pan et al.
Cell death & disease, 9(11), 1077-1077 (2018-10-24)
Amyloid precursor protein (APP) is ubiquitously expressed in various types of cells including bone cells. Mutations in App gene result in early-onset Alzheimer's disease (AD). However, little is known about its physiological function in bone homeostasis. Here, we provide evidence
Qi Ma et al.
Journal of Cancer, 10(21), 5114-5123 (2019-10-12)
Sinularin, a soft corals-derived natural product, exerts anti-tumorigenic activity in various types of human cancer cells. However, the action of Sinularin and its mechanism in renal carcinoma is not well understood. In the current study, we demonstrated that Sinularin inhibited
Pinjia Chen et al.
Free radical biology & medicine, 104, 280-297 (2017-01-31)
Autophagy plays a key role in supporting cell survival against chemotherapy-induced apoptosis. In this study, we found the chemotherapy agent SN-38 induced autophagy in colorectal cancer (CRC) cells. However, inhibition of autophagy using a small molecular inhibitor 3-methyladenine (3-MA) and
Qing Tian et al.
Oxidative medicine and cellular longevity, 2020, 1295382-1295382 (2020-10-31)
Excess iron has been reported to lead to osteoblastic cell damage, which is a crucial pathogenesis of iron overload-related osteoporosis. However, the cytotoxic mechanisms have not been fully documented. In the present study, we focused on whether necroptosis contributes to
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