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Tillmann Bork et al.
Autophagy, 16(11), 1932-1948 (2019-12-24)
While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve long-lived podocytes at the filtration barrier, MTOR regulates at the same time podocyte size and compensatory hypertrophy. Since MTOR is known to generally suppress autophagy, the apparently independent regulation
Mi Sun Sung et al.
Investigative ophthalmology & visual science, 56(5), 3149-3158 (2015-05-30)
To investigate the efficacy of topical 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) in a mouse model of experimental dry eye (EDE). Eye drops consisting of 0.001% or 0.01% AICAR, 0.05% cyclosporine A (CsA), or balanced salt solution (BSS) were applied for the treatment of
S-J Shu et al.
European review for medical and pharmacological sciences, 21(8), 1709-1721 (2017-05-10)
To investigate the effect of second messenger pathways on the uterine smooth muscle contraction and their associated mechanisms, and compare the evaluation methods. Preparation of uterine smooth muscle strips from healthy pregnant 18-21 d SD and non-pregnant rats. When the
Adrian Buensuceso et al.
Molecular cancer research : MCR, 18(3), 488-500 (2019-11-21)
Epithelial ovarian cancer (EOC) spreads by direct dissemination of malignant cells and multicellular clusters, known as spheroids, into the peritoneum followed by implantation and growth on abdominal surfaces. Using a spheroid model system of EOC metastasis, we discovered that Liver
Ze-Tan Chen et al.
Molecular medicine reports, 12(2), 1868-1876 (2015-04-16)
It was previously reported that poly-(adenosine diphosphate-ribose) polymerase-1 (PARP-1) regulated ionizing radiation (IR)-induced autophagy in CNE-2 human nasopharyngeal carcinoma cells. The present study aimed to investigate whether PARP-1-mediated IR-induced autophagy occurred via activation of the liver kinase B1 (LKB1)/adenosine monophosphate-activated
Houssein S Abdou et al.
Molecular and cellular biology, 34(23), 4257-4271 (2014-09-17)
Steroid hormones regulate essential physiological processes, and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by luteinizing hormone (LH) via its receptor leading to increased cyclic AMP (cAMP) production and expression of
Ofer Shamni et al.
Biochimica et biophysica acta, 1859(10), 1900-1910 (2017-06-27)
The rate of glucose influx to skeletal muscles is determined primarily by the number of functional units of glucose transporter-4 (GLUT4) in the myotube plasma membrane. The abundance of GLUT4 in the plasma membrane is tightly regulated by insulin or
Kalliopi-Ioanna Kostaki et al.
Plant physiology, 182(3), 1404-1419 (2020-01-18)
High temperature promotes guard cell expansion, which opens stomatal pores to facilitate leaf cooling. How the high-temperature signal is perceived and transmitted to regulate stomatal aperture is, however, unknown. Here, we used a reverse-genetics approach to understand high temperature-mediated stomatal
Samy L Habib et al.
Cell cycle (Georgetown, Tex.), 15(22), 3048-3059 (2016-10-21)
Exposure of renal cells to high glucose (HG) during diabetes has been recently proposed to be involved in renal injury. In the present study, we investigated a potential mechanism by which AICAR treatment regulates the DNA repair enzyme, 8-oxoG-DNA glycosylase
Yan Wu et al.
Molecular and cellular biochemistry, 411(1-2), 299-305 (2015-10-27)
The aim of the present study was to determine the effect of AICAR, an AMPK activator, on apoptosis in gastric carcinoma cells (SGC-7901) with or without 5-fluorouracil (5-FU). SGC-7901 cells were treated with AICAR (0.2-5 mM, for 24-48 h) with or without
Shigekazu Murakami et al.
Developmental cell, 51(1), 113-128 (2019-08-27)
Employing inducible genetically engineered and orthotopic mouse models, we demonstrate a key role for transcriptional regulator Yap in maintenance of Kras-mutant pancreatic tumors. Integrated transcriptional and metabolomics analysis reveals that Yap transcribes Myc and cooperates with Myc to maintain global
Yamei Han et al.
Nature communications, 10(1), 623-623 (2019-02-09)
Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, the upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation of Insig. Thr222 phosphorylation following AMPK activation
E C Bowdridge et al.
Reproductive biology and endocrinology : RB&E, 15(1), 76-76 (2017-09-25)
Mural granulosa cells from IVF patients were provided by the West Virginia University Center for Reproductive Medicine in Morgantown, WV. The effect of adenosine monophosphate activated protein kinase (AMPK) activation, primary cause of infertility, age, BMI, and pregnancy outcome on
Sophie Dennhardt et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(4), 774-781 (2019-01-21)
Breakdown of the endothelial barrier is a critical step in the development of organ failure in severe inflammatory conditions such as sepsis. Endothelial cells from different tissues show phenotypic variations which are often neglected in endothelial research. Sphingosine-1-phosphate (S1P) and
Estelle N H Youl et al.
Toxicology in vitro : an international journal published in association with BIBRA, 65, 104811-104811 (2020-03-03)
Aristolochic acid nephropathy (AAN) is characterized by interstitial fibrosis, proximal tubular atrophy, and hypoxia. A correlation between a reduced peritubular capillary density and the severity of fibrosis has been demonstrated. As calcium, redox and energetic homeostasis are crucial in maintaining
Yanling Sui et al.
Neural regeneration research, 9(19), 1770-1778 (2014-11-26)
Alterations in embryonic neural stem cells play crucial roles in the pathogenesis of amyotrophic lateral sclerosis. We hypothesized that embryonic neural stem cells from SOD1(G93A) individuals might be more susceptible to oxidative injury, resulting in a propensity for neurodegeneration at
Andreas Prokesch et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(2), 732-742 (2016-11-05)
The ability to adapt cellular metabolism to nutrient availability is critical for survival. The liver plays a central role in the adaptation to starvation by switching from glucose-consuming processes and lipid synthesis to providing energy substrates like glucose to the
Xin Liu et al.
Scientific reports, 6, 39735-39735 (2016-12-23)
Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus flavonoid with remarkable anti-inflammatory activity, but the mechanisms underlying its inhibition of LPS/TLR4
Guilherme Silva Ferreira et al.
Frontiers in physiology, 8, 644-644 (2017-09-21)
Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis, uptake, and exportation besides mediating inflammation and cytotoxicity that modulate the development of atherosclerosis. Aerobic exercise training (AET) prevents and regresses atherosclerosis by the improvement of lipid metabolism, reverse cholesterol
Naomi Rozentul et al.
Pharmaceutical research, 34(12), 2873-2890 (2017-10-07)
A series of novel polycyclic aromatic compounds that augment the rate of glucose uptake in L6 myotubes and increase glucose-stimulated insulin secretion from beta-cells were synthesized. Designing these molecules, we have aimed at the two main pathogenic mechanisms of T2D
Hui Lin et al.
Molecular pharmacology, 88(6), 1062-1071 (2015-10-02)
AMP-activated protein kinase (AMPK), an important downstream effector of the tumor suppressor liver kinase 1 (LKB1) and pharmacologic target of metformin, is well known to exert a preventive and inhibitory effect on tumorigenesis; however, its role in cancer progression and
Yasuki Naito et al.
Development (Cambridge, England), 147(14) (2020-06-20)
The microtubule motor cytoplasmic dynein contributes to radial migration of newborn pyramidal neurons in the developing neocortex. Here, we show that AMP-activated protein kinase (AMPK) mediates the nucleus-centrosome coupling, a key process for radial neuronal migration that relies on dynein.
Teraneh Z Jhaveri et al.
Oncotarget, 6(17), 14754-14765 (2015-07-06)
AMP-activated Protein Kinase (AMPK) activity retards growth of many types of cancers. Investigating effects of AMPK activation on breast cancer cell signaling and survival, we found that breast cancer cell lines with amplification and over-expression of HER2 or EGFR are
Min Jeong Chun et al.
FEBS open bio, 7(2), 284-292 (2017-02-09)
FANCD2 is a pivotal molecule in the pathogenesis of Fanconi anemia (FA), an autosomal recessive human syndrome with diverse clinical phenotypes, including cancer predisposition, short stature, and hematological abnormalities. In our previous study, we detected the functional association of FANC
Fengyun Wen et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 53(2), 132-144 (2020-12-11)
Resistin was identified as a link between obesity and insulin resistance and is associated with many diseases in mice. Deciphering the related development and molecular mechanism is necessary for the treatment of these diseases. Previous studies have revealed that increased
Marin E Nelson et al.
The EMBO journal, 38(24), e102578-e102578 (2019-08-06)
Exercise stimulates cellular and physiological adaptations that are associated with widespread health benefits. To uncover conserved protein phosphorylation events underlying this adaptive response, we performed mass spectrometry-based phosphoproteomic analyses of skeletal muscle from two widely used rodent models: treadmill running
Xiao Huang et al.
The Plant cell, 31(12), 2973-2995 (2019-10-17)
Under nutrient and energy-limiting conditions, plants up-regulate sophisticated catabolic pathways such as autophagy to remobilize nutrients and restore energy homeostasis. Autophagic flux is tightly regulated under these circumstances through the AuTophaGy-related1 (ATG1) kinase complex, which relays upstream nutrient and energy
Susana Peralta et al.
Human molecular genetics, 25(15), 3178-3191 (2016-06-12)
Acute pharmacological activation of adenosine monophosphate (AMP)-kinase using 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside (AICAR) has been shown to improve muscle mitochondrial function by increasing mitochondrial biogenesis. We asked whether prolonged AICAR treatment is beneficial in a mouse model of slowly progressing mitochondrial myopathy (Cox10-Mef2c-Cre)
Lara Faggi et al.
Molecular and cellular endocrinology, 470, 60-74 (2017-10-01)
For a few years we have been investigating AMP-activated protein kinase (AMPK) as a target for drug therapy of GH-secreting pituitary adenomas. Aim of this study was to investigate the direct effects of metformin, which causes AMPK activation in different
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