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Carla Barceló et al.
The Journal of investigative dermatology, 140(6), 1253-1265 (2019-12-27)
Melanoma is a malignant neoplasia that is highly resistant to chemotherapy and radiotherapy and is associated with poor prognosis in advanced stage. Targeting melanoma that harbors the common BRAFV600E mutation with kinase inhibitors, such as vemurafenib, reduces tumor burden, but
Mónica Salas Rojas et al.
Viruses, 13(1) (2021-01-23)
Quinacrine (Qx), a molecule used as an antimalarial, has shown anticancer, antiprion, and antiviral activity. The most relevant antiviral activities of Qx are related to its ability to raise pH in acidic organelles, diminishing viral enzymatic activity for viral cell
Guillaume Morin et al.
Cells, 9(8) (2020-07-28)
Nowadays, aquaculture provides more than 50% of fish consumed worldwide but faces new issues that challenge its sustainability. One of them relies on the replacement of fish meal (FM) in aquaculture feeds by other protein sources without deeply affecting the
Xu-Xu Zhuang et al.
Cell death & disease, 11(2), 128-128 (2020-02-20)
Autophagy, a conserved cellular degradation and recycling process, can be enhanced by nutrient depletion, oxidative stress or other harmful conditions to maintain cell survival. 6-Hydroxydopamine/ascorbic acid (6-OHDA/AA) is commonly used to induce experimental Parkinson's disease (PD) lesions by causing oxidative
Abdelhalim Babiker Mahmoud et al.
Frontiers in pharmacology, 11, 1246-1246 (2020-09-15)
In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against
Yuan Zhao et al.
Ecotoxicology and environmental safety, 208, 111743-111743 (2021-01-06)
Autophagy dysregulation plays a pivotal role in cadmium (Cd)-induced nephrotoxicity. Quercetin (Qu), a flavonoid antioxidant with autophagy-enhancing effect, has protective effect on Cd-induced toxicity, but whether it can prevent Cd-induced nephrotoxicity via restoration of autophagy remains unknown. Here, primary rat
Laurent-Olivier Roy et al.
Investigational new drugs, 33(5), 1020-1031 (2015-08-15)
Glioblastoma (GBM), the most common and aggressive primary brain tumor, is characterized by excessive brain infiltration which prevents the complete surgical resection. These tumors also display treatment non-compliance and responses to standard therapy are invariably transient; consequently, the prognosis barely
Marc Thibault et al.
Biomaterials, 32(20), 4639-4646 (2011-04-01)
The optimal ratio of the polycation's amine to DNA phosphate group (N:P) for efficient polymer-based transfection always employs excess polycation versus DNA. Most of the excess polycation remains free in solution, unassociated with the polyplexes, but is essential for efficient
Lei-Ke Zhang et al.
Cell discovery, 6(1), 96-96 (2020-12-23)
The coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread to >200 countries posing a global public health concern. Patients with comorbidity, such as hypertension suffer more severe infection with elevated mortality.
Philippa J Goddard et al.
Cell reports, 27(4), 1008-1017 (2019-04-25)
Microbial infections can stimulate the assembly of inflammasomes, which activate caspase-1. The gastrointestinal pathogen enteropathogenic Escherichia coli (EPEC) causes localized actin polymerization in host cells. Actin polymerization requires the binding of the bacterial adhesin intimin to Tir, which is delivered
Rajnish Kumar Singh et al.
eLife, 10 (2021-07-20)
The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi's sarcoma associated herpesvirus (KSHV) infected cells maintains replication
Risheng Ye et al.
The American journal of pathology, 189(4), 813-825 (2019-01-18)
Syntrophins are a family of proteins forming membrane-anchored scaffolds and serving as adaptors for various transmembrane and intracellular signaling molecules. To understand the physiological roles of β1 syntrophin, one of the least characterized members, we generated mouse models to eliminate
Nils Rother et al.
Cell reports. Medicine, 1(9), 100146-100146 (2020-12-31)
Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses
Xin Tang et al.
Thoracic cancer, 12(8), 1219-1230 (2021-03-04)
Emerging studies showed curcumin can inhibit glioblastoma and breast cancer cells via regulating ferroptosis. However, the role of ferroptosis in the inhibitory effect of curcumin on non-small-cell lung cancer (NSCLC) remains unclear. Cell counting kit-8 (CCK-8) assay was used to
Jinyu Wei et al.
American journal of physiology. Cell physiology, 318(5), C1018-C1029 (2020-04-16)
Autophagy is a highly conserved self-protection mechanism that plays a crucial role in cardiovascular diseases. Cardiomyocyte hypoxic injury promotes oxidative stress and pathological alterations in the heart, although the interplay between these effects remains elusive. The transient receptor potential vanilloid
T B Di Giacomo et al.
Lupus, 18(3), 264-266 (2009-02-14)
A case of hair depigmentation induced by chloroquine diphosphate subacute overdosage in an 11-year-old patient with dermatomyositis is presented. Normal coloured hair growth occurred after normalisation of chloroquine dosage. A discussion on possible pathomechanisms of this phenomenon is made based
Manisha Sathe et al.
Bioorganic & medicinal chemistry letters, 20(14), 4233-4236 (2010-06-24)
A novel series of semi-synthetic gomphostenin derivatives (1-9) were prepared utilizing C-14 hydroxyl group for the first time and studied for their antimalarial properties. In vitro antiplasmodial activity was evaluated against both the chloroquine sensitive and resistant strains of Plasmodium
Ingeborg Walter-Sack et al.
European journal of clinical pharmacology, 65(2), 179-189 (2008-09-24)
Methylene blue (MB) has recently been reevaluated for malaria treatment. With the aim of excluding treatment failures due to low bioavailability, we have investigated the absolute bioavailability of MB given as an aqueous oral formulation and its interaction with chloroquine
Shaoqing Shi et al.
Oncotarget, 6(3), 1640-1651 (2015-02-16)
Drug resistance is a major hurdle in anticancer chemotherapy. Combined therapy using drugs with distinct mechanisms of function may increase anticancer efficacy. We have recently identified the novel chalcone derivative, chalcone-24 (Chal-24), as a potential therapeutic that kills cancer cells
Marina Galvão Bueno et al.
Veterinary parasitology, 173(1-2), 123-127 (2010-07-20)
This study reports avian malaria caused by Plasmodium relictum in Magellanic Penguins (Spheniscus magellanicus) from São Paulo Zoo. The disease was highly infective among the birds and was clinically characterized by its acute course and high mortality. The penguins of
Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
Petritsch, et al.
European Journal of Medicinal Chemistry, 210, 112969-112969 (2021)
Chakravarthy Garlapati et al.
Theranostics, 11(18), 9089-9106 (2021-09-16)
Rationale: Cancer cells rely on glucose metabolism for fulfilling their high energy demands. We previously reported that monoethanolamine (Etn), an orally deliverable lipid formulation, reduced intracellular glucose and glutamine levels in prostate cancer (PCa). Glucose deprivation upon Etn treatment exacerbated
Huichao Huang et al.
Aging, 12(14), 14699-14717 (2020-07-18)
Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that
Yunjiao Zhang et al.
Nature communications, 9(1), 4236-4236 (2018-10-14)
Chemo-PTT, which combines chemotherapy with photothermal therapy, offers a viable approach for the complete tumor eradication but would likely fail in drug-resistant situations if conventional chemotherapeutic agents are used. Here we show that a type of copper (Cu)-palladium (Pd) alloy
Kana Nakatani et al.
International journal of hematology, 113(2), 243-253 (2020-10-18)
The t(8;21) translocation is the most common cytogenetic abnormality in acute myeloid leukemia (AML). Although t(8;21) AML patients have a relatively favorable prognosis, relapse is a frequent occurrence, underscoring the need to develop novel therapeutic approaches. Here, we showed that
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Femke C C Klouwer et al.
Frontiers in cell and developmental biology, 9, 661298-661298 (2021-04-20)
Peroxisome biogenesis disorders within the Zellweger spectrum (PBD-ZSDs) are most frequently associated with the c.2528G>A (p.G843D) mutation in the PEX1 gene (PEX1-G843D), which results in impaired import of peroxisomal matrix proteins and, consequently, defective peroxisomal functions. A recent study suggested
Tai-Qiang Chen et al.
International journal of biological sciences, 16(7), 1252-1263 (2020-03-17)
Although EHMT2 (also known as G9a) plays a critical role in several kinds of cancers and cardiac remodeling, its function in vascular smooth muscle cells (VSMCs) remains unknown. In the present study, we revealed a novel function of EHMT2 in
Yueyang Liu et al.
Autophagy, 15(3), 493-509 (2018-10-12)
Mounting attention has been focused on defects in macroautophagy/autophagy and the autophagy-lysosomal pathway (ALP) in cerebral ischemia. TFEB (transcription factor EB)-mediated induction of ALP has been recently considered as the common mechanism in ameliorating the pathological lesion of myocardial ischemia
Sasikala Muthusamy et al.
Journal of biomedical science, 28(1), 72-72 (2021-10-29)
During autophagy defense against invading microbes, certain lipid types are indispensable for generating specialized membrane-bound organelles. The lipid composition of autophagosomes remains obscure, as does the issue of how specific lipids and lipid-associated enzymes participate in autophagosome formation and maturation.
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