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Ewelina Aleksander-Konert et al.
Cellular & molecular biology letters, 21, 11-11 (2017-05-26)
In this study, we evaluated the usefulness of two commercially available hyaluronic acid-based hydrogels, HyStem and HyStem-C, for the cultivation of Wharton's jelly mesenchymal stem cells (WJ-MSCs) and their differentiation towards chondrocytes. The WJ-MSCs were isolated from umbilical cord Wharton's...
Kristine Ravina et al.
International journal of molecular sciences, 19(12) (2018-11-30)
Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived...
Tatsuki Ogasawara et al.
Scientific reports, 7(1), 8630-8630 (2017-08-19)
Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has...
Hal Sternberg et al.
Regenerative medicine, 7(4), 481-501 (2012-04-24)
We screened 100 diverse human embryonic stem-derived progenitor cell lines to identify novel lines with chondrogenic potential. The 4D20.8 cell line was compared with mesenchymal stem cells and dental pulp stem cells by assessing osteochondral markers using immunohistochemical methods, gene...
Xia Chen et al.
Journal of tissue engineering and regenerative medicine, 10(5), 437-446 (2013-05-09)
Mesenchymal stromal cells (MSCs) are multipotential adult cells present in all tissues. Paracrine effects and differentiating ability make MSCs an ideal cell source for tissue regeneration. However, little is known about how interactions between implanted MSCs and native cells influence...
D Chen et al.
Eye (London, England), 31(6), 962-971 (2017-02-18)
PurposeTo develop a hyaluronan hydrogel scaffold-based xeno-free culture system for ex vivo cultivation of human corneal epithelial stem cells (CESCs).Patients and MethodsCESCs were cultivated from donor limbal explants on the HyStem-C Hydrogel bio-scaffold in 12-well plates for 3 weeks. Group...
Douglas O Sobel et al.
Islets, 12(4), 71-86 (2020-06-23)
Immortalized beta cells are an abundant source of insulin-producing cells. Although MIN-6 cells have similar characteristics as normal islets in vitro, the in vivo use of MIN-6 cells has not been fully described. This study characterizes in vivo mouse models...
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