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Atsufumi Kawabata
Biological & pharmaceutical bulletin, 34(8), 1170-1173 (2011-08-02)
Prostaglandin E(2) (PGE(2)), a cyclooxygenase (COX) product, is the best known lipid mediator that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing generation of prostanoids, mainly PGE(2), while they exhibit
Takashi Morisaki et al.
Anticancer research, 33(4), 1387-1395 (2013-04-09)
Sorafenib is a promising treatment for hepatocellular carcinoma (HCC) but recent toxicity concerns suggest that new strategies for its use are needed. One approach for reducing toxicity is to use lower doses of sorafenib in combination with other complementary mechanisms.
Yolanda Mendizábal et al.
Life sciences, 93(25-26), 1023-1032 (2013-11-10)
We have studied the vasoactive role of prostaglandins derived from perivascular adipose tissue (PVAT) and their effects on endothelial function in healthy rats and rats with metabolic syndrome (SHROB). Mesenteric resistance arteries (MRA) from SHROB and control rats (WKY) were
Jong Hwan Kwak et al.
Biomaterials, 61, 52-60 (2015-05-23)
We studied the blood-brain barrier (BBB) permeability and intracellular localization of a fluorescein isothiocyanate (FITC)-labeled dieckol (1) and a rhodamine B-labeled dieckol (7), for exploring the possible therapeutic application of fluorone-labeled dieckols in neurodegenerative diseases. Both compounds (1 &7) were
Astrid Stefanie Kahnt et al.
Biochemical pharmacology, 86(2), 286-296 (2013-05-21)
Because of their favourable safety profile and beneficial anti-inflammatory properties, the CysLT1 receptor antagonists (LTRA), montelukast, zafirlukast and pranlukast are approved for the treatment of asthma and are frequently prescribed as add-on therapeutics to reduce the amount of inhaled glucocorticoids
Kristen R Crook et al.
Journal of leukocyte biology, 97(3), 573-582 (2015-01-15)
MDSCs are a heterogeneous group of myeloid cells that suppress T cell activity in cancer and autoimmune disease. The effect of MDSCs on B cell function is not clear. Using the CIA model of autoimmune disease, we found an increase
Targeting the inflammatory response in tuberculosis.
Jon S Friedland
The New England journal of medicine, 371(14), 1354-1356 (2014-10-02)
A L Rozza et al.
Chemico-biological interactions, 206(2), 272-278 (2013-10-15)
Based on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from species of the genus Mentha.
Ju-Mi Hong et al.
International journal of molecular medicine, 35(5), 1403-1410 (2015-03-05)
Canarium lyi C.D. Dai & Yakovlev (CL) is a member of the Anacardiaceae family. To the best of our knowledge, no studies on its anti-inflammatory effects have yet been reported. In the present study, we investigated the protective effects of
Concepción Sánchez-Moreno et al.
The Journal of nutrition, 133(7), 2204-2209 (2003-07-04)
We examined the bioavailability of vitamin C in orange juice processed using high pressure (HP) and its effects on plasma levels of vitamin C, uric acid (UA), F2-isoprostanes (8-epiPGF(2alpha)), C-reactive protein (CRP) and prostaglandin E(2) (PGE(2)) in a healthy human
Thatiana Lopes Biá Ventura et al.
Molecules (Basel, Switzerland), 20(5), 8072-8093 (2015-05-08)
Tuberculosis (TB) remains a serious public health problem aggravated by the emergence of M. tuberculosis (Mtb) strains resistant to multiple drugs (MDR). Delay in TB treatment, common in the MDR-TB cases, can lead to deleterious life-threatening inflammation in susceptible hyper-reactive
António Galvão et al.
Mediators of inflammation, 2014, 682193-682193 (2014-08-16)
Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and
Johanna C Sierra et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(2), G196-G203 (2013-05-18)
Chronic infection of the gastric mucosa by Helicobacter pylori is associated with an increased risk of developing gastric cancer; however, the vast majority of infected individuals never develop this disease. One H. pylori virulence factor that increases gastric cancer risk
Yi Yun Pang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71, 207-216 (2014-06-24)
2-Phenylaminophenylacetic acid is a widely-exploited chemical scaffold whereby notable NSAIDs such as diclofenac and lumiracoxib were derived. Yet, their clinical usage has been associated with toxicities in the liver. While some studies have attributed toxicities to the bioactivation of both
Takeshi Kobayashi et al.
Experimental eye research, 135, 109-117 (2015-02-17)
Interactions between stromal and epithelial cells play important roles in the development, homeostasis, and pathological conditions of the cornea. Soluble cytokines are critical factors in stromal-epithelial interactions, and growth factors secreted from corneal stromal cells contribute to the regulation of
Xiaofeng Niu et al.
International immunopharmacology, 24(2), 432-439 (2015-01-18)
Acute lung injury (ALI) is a life-threatening disease characterized by serious lung inflammation and increased capillary permeability, which presents a high mortality worldwide. Isofraxidin (IF), a Coumarin compound isolated from the natural medicinal plants such as Sarcandra glabra and Acanthopanax
J Y Westcott et al.
Prostaglandins, 34(6), 877-887 (1987-12-01)
Recent evidence has shown that a variety of prostaglandins and leukotrienes can be produced in brain tissue after injury in animals. It has also been speculated that increases in brain prostaglandins occur in humans following injury. Ventricular cerebrospinal fluid (CSF)
Sabrina Fichtner et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1712-1721 (2015-01-23)
Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma
Marjolaine A Pelissier-Rota et al.
The international journal of biochemistry & cell biology, 65, 239-256 (2015-06-24)
Nicotine, one of the active components in cigarette smoke, has been described to contribute to the protective effect of smoking in ulcerative colitis (UC) patients. Furthermore, the nicotinic acetylcholine receptor α7 subunit (α7nAChR) expressed on immune cells, is an essential
Liu Liu et al.
Stem cells international, 2020, 2803747-2803747 (2020-05-08)
Adipose-derived mesenchymal stem cells (ADMSCs) have been used for treating tissue injury, and preactivation enhances their therapeutic effect. This study is aimed at investigating the therapeutic effect of activated ADMSCs by IL-1β on the intestinal ischaemia-reperfusion (IR) injury and exploring
Sojin Kim et al.
Biochemical and biophysical research communications, 456(1), 167-172 (2014-12-03)
Gastrointestinal disorder is a common symptom induced by diverse pathophysiological conditions that include food tolerance, chemotherapy, and irradiation for therapy. Prostaglandin E2 (PGE2) level increase was often reported during gastrointestinal disorder and prostaglandin synthetase inhibitors has been used for ameliorate
Alexandra Medeiros et al.
Mediators of inflammation, 2012, 327568-327568 (2012-10-02)
The local and systemic production of prostaglandin E(2) (PGE(2)) and its actions in phagocytes lead to immunosuppressive conditions. PGE(2) is produced at high levels during inflammation, and its suppressive effects are caused by the ligation of the E prostanoid receptors
Antonina V Kurtova et al.
Nature, 517(7533), 209-213 (2014-12-04)
Cytotoxic chemotherapy is effective in debulking tumour masses initially; however, in some patients tumours become progressively unresponsive after multiple treatment cycles. Previous studies have demonstrated that cancer stem cells (CSCs) are selectively enriched after chemotherapy through enhanced survival. Here we
Nicholas S Kirkby et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4568-4578 (2015-07-18)
Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-function
Yu-Cui Li et al.
Journal of ethnopharmacology, 157, 212-221 (2014-09-27)
Pogostemon cablin (Blanco) Benth is a well-known medicinal herb commonly used in many Asian countries for inflammatory diseases. Pogostone (PO), a natural product isolated from Pogostemon cablin, is known to exert various pharmacological activities. This study aimed to investigate the
Christina E Swan et al.
Prostaglandins & other lipid mediators, 96(1-4), 10-13 (2011-08-02)
Hypertension is a well established risk factor for cardiovascular diseases such as stroke and is the leading cause of chronic kidney failure. Although a number of pharmacologic agents are available for the treatment of hypertension including agents that affect the
S D Romero et al.
Journal of neurochemistry, 43(6), 1642-1649 (1984-12-01)
Prostaglandins are involved in the modulation of various central functions (neurotransmitters and hypothalamic hormone release, thermoregulation, cerebrovascular tone) and their levels increase in pathological situations [subarachnoid hemorrhage (SAH), stroke, convulsive disorders, etc.]. This study, using sensitive and specific antibodies, examined
Werner Seebacher et al.
European journal of medicinal chemistry, 101, 552-559 (2015-07-22)
Several new 4-phenylpyrimidine-2(1H)-thiones have been prepared and investigated for their potencies to inhibit COX-1 and COX-2 enzymes, and COX-2 expression in THP-1 cells. Structure-activity-relationships and physicochemical parameters are discussed. Pharmacophore screening and docking studies were carried out for the most
Woo Jin Yun et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(12), 1903-1911 (2013-10-18)
Epidermal growth factor (EGF) is a peptide that promotes cell growth by binding to its receptor (EGFR) on the cell surface. EGF has been used in cosmetics to whiten the skin and for the prevention of postinflammatory hyperpigmentation (PIH), presumably
Diana Serra et al.
PloS one, 9(10), e109048-e109048 (2014-10-02)
Many advances have been recently made focused on the valuable help of dietary polyphenols in chronic inflammatory diseases. On the other hand, current treatment options for intestinal bowel disease patients are unsatisfying and, for this reason, it is estimated that
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