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Anantha Koteswararao Kanugula et al.
The FEBS journal, 281(16), 3719-3738 (2014-06-27)
Accumulating evidence from in vitro, in vivo, clinical and epidemiological studies shows promising results for the use of statins against many cancers including breast carcinoma. However, the molecular mechanisms responsible for the anti-proliferative and anti-invasive properties of statins still remain elusive. In
Hironao Takasawa et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 144-150 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative International Validation Study of an in vivo rat alkaline comet assay, we examined 1,2-dibromoethane (DBE), p-anisidine (ASD), and o-anthranilic acid (ANT) to investigate the effectiveness of the
Milda Norkiene et al.
BMC biotechnology, 15, 68-68 (2015-08-05)
Eleven new human polyomaviruses (HPyVs) have been identified in the last decade. Serological studies show that these novel HPyVs sub-clinically infect humans at an early age. The routes of infection, entry pathways, and cell tropism of new HPyVs remain unknown.
Ina Ulrich et al.
Clinical oral investigations, 19(6), 1473-1483 (2014-12-09)
The objectives of this study were to evaluate ex vivo the effects of resin infiltration on the areal surface roughness of natural non-cavitated proximal subsurface lesions with or without previous deproteinization and to determine differences between E2 and D1 lesions
Gillian N Pike et al.
Blood, 126(3), 397-405 (2015-04-26)
Individuals with Factor XI (FXI) deficiency have a variable bleeding tendency that does not correlate with FXI:C levels or genotype. Comparing a range of sample conditions, we tested whether the thrombin generation assay (TGA) could discriminate between control subjects (n
C Paiva et al.
Cell death & disease, 6, e1807-e1807 (2015-07-15)
Microenvironment-mediated upregulation of the B-cell receptor (BCR) and nuclear factor-κB (NF-κB) signaling in CLL cells resident in the lymph node and bone marrow promotes apoptosis evasion and clonal expansion. We recently reported that MLN4924 (pevonedistat), an investigational agent that inhibits
Emma Puighermanal et al.
Hippocampus, 25(7), 858-875 (2014-12-30)
Increasing evidences suggest that dopamine facilitates the encoding of novel memories by the hippocampus. However, the role of dopamine D2 receptors (D2R) in such regulations remains elusive due to the lack of the precise identification of hippocampal D2R-expressing cells. To
Shankha Satpathy et al.
Molecular systems biology, 11(6), 810-810 (2015-06-04)
B-cell receptor (BCR) signaling is essential for the development and function of B cells; however, the spectrum of proteins involved in BCR signaling is not fully known. Here we used quantitative mass spectrometry-based proteomics to monitor the dynamics of BCR
Marie Lambelé et al.
Journal of virology, 89(6), 3247-3255 (2015-01-09)
Tetraspanins constitute a family of cellular proteins that organize various membrane-based processes. Several members of this family, including CD81, are actively recruited by HIV-1 Gag to viral assembly and release sites. Despite their enrichment at viral exit sites, the overall
A P Shabanzadeh et al.
Cell death & disease, 6, e1744-e1744 (2015-05-08)
The dependence receptor Neogenin and its ligand, the repulsive guidance molecule a (RGMa), regulate apoptosis and axonal growth in the developing and the adult central nervous system (CNS). Here, we show that this pathway has also a critical role in
Jennifer A Martin et al.
Analytical and bioanalytical chemistry, 406(19), 4637-4647 (2014-06-02)
The first-known aptamer for the stress biomarker cortisol was selected using a tunable stringency magnetic bead selection strategy. The capture DNA probe immobilized on the beads was systematically lengthened to increase the number of bases bound to the complementary pool
Howard M Saal et al.
Human molecular genetics, 24(12), 3399-3409 (2015-03-12)
Autosomal dominant omodysplasia is a rare skeletal dysplasia characterized by short humeri, radial head dislocation, short first metacarpals, facial dysmorphism and genitourinary anomalies. We performed next-generation whole-exome sequencing and comparative analysis of a proband with omodysplasia, her unaffected parents and
Brandi S Betts-Obregon et al.
Investigative ophthalmology & visual science, 55(10), 6265-6271 (2014-09-04)
Interphotoreceptor retinoid-binding protein's (IRBP) role in facilitating the exchange of retinoids between rod and cone photoreceptors, RPE, and Müller cells in the visual cycle remains a mystery. Interphotoreceptor retinoid-binding protein's ability to bind the pericellular matrix of the cone outer
Peng Yi et al.
Molecular biology of the cell, 26(1), 29-42 (2014-11-08)
The Cdo-p38MAPK (p38 mitogen-activated protein kinase) signaling pathway plays important roles in regulating skeletal myogenesis. During myogenic differentiation, the cell surface receptor Cdo bridges scaffold proteins BNIP-2 and JLP and activates p38MAPK, but the spatial-temporal regulation of this process is
Almudena Crooke et al.
Current eye research, 40(1), 56-65 (2014-06-04)
We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all
Jan E Janecka et al.
The Journal of experimental biology, 218(Pt 15), 2402-2409 (2015-08-08)
Genetically based modifications of hemoglobin (Hb) function that increase blood-O2 affinity are hallmarks of hypoxia adaptation in vertebrates. Among mammals, felid Hbs are unusual in that they have low intrinsic O2 affinities and reduced sensitivities to the allosteric cofactor 2,3-diphosphoglycerate
Michele Scarola et al.
Nature communications, 6, 7631-7631 (2015-07-15)
Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (mESCs) self-renewal. Sense Oct4P4
Fattah Sotoodehnejadnematalahi et al.
PloS one, 10(6), e0125799-e0125799 (2015-06-10)
Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for hypoxic induction are not
Guohua Gong et al.
American journal of physiology. Heart and circulatory physiology, 309(7), H1166-H1177 (2015-08-16)
Mitochondrial respiration through electron transport chain (ETC) activity generates ATP and reactive oxygen species in eukaryotic cells. The modulation of mitochondrial respiration in vivo or under physiological conditions remains elusive largely due to the lack of appropriate approach to monitor
Lei Yu et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(6), 747-755 (2014-11-06)
Orexin deficiency results in cataplexy, a motor deficit characterized by sudden loss of muscle tone, strongly indicating an active role of central orexinergic system in motor control. However, effects of orexin on neurons in central motor structures are still largely
Silvia Di Prisco et al.
Synapse (New York, N.Y.), 68(11), 529-535 (2014-08-06)
In cortical synaptosomes of Experimental Autoimmune Encephalomyelitis (EAE) mice at the early stage of disease (13 days post immunization, d.p.i.), the Regulated upon Activation Normal T cell Expressed and Secreted (RANTES, CCL5)-mediated control of [3H]D-aspartate ([3H]D-ASP) exocytosis elicited by a
N Colin Heath et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(26), 8800-8812 (2014-06-27)
The cerebellum receives sensory information by mossy fiber input from a multitude of sources that require differential signal processing. A compartmentalization of function begins with the segregation of mossy fibers across 10 distinct lobules over the rostrocaudal axis, with tactile
Gajanan Kashinathrao Arbade et al.
Acta crystallographica. Section F, Structural biology communications, 71(Pt 6), 763-769 (2015-06-10)
Staphylococcus aureus is an important human and animal pathogen that causes a wide range of infections. The prevalence of multidrug-resistant S. aureus strains in both hospital and community settings makes it imperative to characterize new drug targets to combat S.
Syed Raziuddin Quadri et al.
The Journal of antibiotics, 68(8), 491-495 (2015-03-19)
A Gram-positive, aerobic, nonmotile actinomycete strain designated DRQ-2(T) was isolated from the soil sample collected from lime-stone open pit mine from the Gulbarga region, Karnataka province, India. Strain DRQ-2(T) was identified as a member of the genus Nonomuraea by a
Peiying Shi et al.
BMC complementary and alternative medicine, 15, 225-225 (2015-07-15)
For a long time, honey was purportedly helpful to prevent drunkenness and relieve hangover symptoms. However, few of the assertions have experienced scientific assessment. The present study examined the effects of honey on intoxicated male mice. Low or high doses
Pierina Visciano et al.
Journal of food protection, 78(9), 1719-1728 (2015-09-01)
Concentrations of pollutants with regulatory limits were determined in specimens of Chamelea gallina, a species of clam collected along the Abruzzi coastal region of the central Adriatic Sea. Nine sampling sites were selected to evaluate the distribution of contaminants in
Viviane A V N Braga et al.
PloS one, 10(4), e0125388-e0125388 (2015-04-30)
Previous studies have shown that estrogen deficiency, arising in postmenopause, promotes endothelial dysfunction. This study evaluated the effects of aerobic exercise training on endothelial dependent vasodilation of aorta in ovariectomized rats, specifically investigating the role of nitric oxide (NO) and
Ilaria Naldi et al.
PloS one, 9(5), e98101-e98101 (2014-05-24)
Epigenetic events are critical contributors to the pathogenesis of cancer, and targeting epigenetic mechanisms represents a novel strategy in anticancer therapy. Classic demethylating agents, such as 5-Aza-2'-deoxycytidine (Decitabine), hold the potential for reprograming somatic cancer cells demonstrating high therapeutic efficacy
Dror Eliaz et al.
RNA biology, 12(11), 1222-1255 (2015-05-15)
Trypanosomatids are protozoan parasites and the causative agent of infamous infectious diseases. These organisms regulate their gene expression mainly at the post-transcriptional level and possess characteristic RNA processing mechanisms. In this study, we analyzed the complete repertoire of Leishmania major
Thiago Berti Kirsten et al.
PloS one, 10(7), e0134565-e0134565 (2015-07-29)
Autism is characterized by social deficits, repetitive behaviors, and cognitive inflexibility. The risk factors appear to include genetic and environmental conditions, such as prenatal infections and maternal dietary factors. Previous investigations by our group have demonstrated that prenatal exposure to
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