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Archana Vijaya Kumar et al.
International journal of cancer, 135(11), 2579-2592 (2014-04-23)
Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer. As HS has an important co-receptor function for numerous signal transduction pathways, the phenotypical changes due to HS3ST2 reexpression were
Mathias P Clausen et al.
PloS one, 9(6), e97671-e97671 (2014-06-04)
Quantum dots are available in a range of spectrally separated emission colors and with a range of water-stabilizing surface coatings that offers great flexibility for enabling bio-specificity. In this study, we have taken advantage of this flexibility to demonstrate that
Sabino Pacheco et al.
AMB Express, 5(1), 73-73 (2015-11-27)
Bacillus thuringiensis (Bt) produces insecticidal proteins that have been used worldwide in the control of insect-pests in crops and vectors of human diseases. However, different insect species are poorly controlled by the available Bt toxins or have evolved resistance to
Jun Fujii et al.
PloS one, 9(5), e93655-e93655 (2014-05-16)
In mice and humans, the androgen receptor (AR) gene, located on the X chromosome, is not known to be involved in sex determination. In the Japanese frog Rana rugosa the AR is located on the sex chromosomes (X, Y, Z
Tian Su et al.
eLife, 4 (2015-02-11)
The transcriptional coactivator Yes-associated protein (Yap) promotes proliferation and inhibits apoptosis, suggesting that Yap functions as an oncogene. Most oncogenes, however, require a combination of at least two signals to promote proliferation. In this study, we present evidence that Yap
Ni Zeng et al.
International journal of pharmaceutics, 467(1-2), 70-83 (2014-04-05)
Thermosensitive hydrogels developed for buccal delivery of salbutamol were prepared using poloxamer analogs (Kolliphor(®) P407/P188), xanthan gum (Satiaxane(®) UCX930) and NaCl. P188 increased gelation temperature (Tsol-gel) by 2.5-5°C, micellization temperature (<1°C) and gelation time by >3s. To obtain a suitable
Manish K Tripathi et al.
Cancer research, 74(23), 6947-6957 (2014-10-17)
Metastatic recurrence is the leading cause of cancer-related deaths in patients with colorectal carcinoma. To capture the molecular underpinnings for metastasis and tumor progression, we performed integrative network analysis on 11 independent human colorectal cancer gene expression datasets and applied
Jun Zhou et al.
British journal of pharmacology, 172(21), 5068-5082 (2015-08-01)
Posttraumatic stress disorder (PTSD) is a mental disorder with enhanced retention of fear memory and has profound impact on quality of life for millions of people worldwide. The β-adrenoceptor antagonist propranolol has been used in preclinical and clinical studies for
Ryota Matsuo et al.
The Journal of comparative neurology, 524(1), 119-135 (2015-06-25)
Terrestrial mollusks can form an odor aversion memory following the simultaneous presentation of a food odor and an aversive stimulus. The local field potential oscillation recorded on the surface of the procerebrum (PC; the higher olfactory center) exhibits a frequency
Simona Boncompagni et al.
The Journal of physiology, 593(12), 2679-2692 (2015-04-08)
Many studies have previously suggested the existence of stress hormone receptors on the cell membrane of many cell types, including skeletal muscle fibres; however, the exact localisation of these receptors and how they signal to the rest of the cell
C H Zheng et al.
European cells & materials, 29, 224-236 (2015-04-22)
The 1,9-dimethylmethylene blue (DMMB) assay is widely used to quantify sulfated glycosaminoglycan (sGAG) contents of engineered tissues, culture media, tissue samples and bodily fluids, but the assay is subject to interference from polyanions such as hyaluronic acid (HA), DNA and
Jadwiga Oczos et al.
Investigative ophthalmology & visual science, 55(8), 4714-4727 (2014-07-17)
Biochemical and genetic analyses established a contribution of lipid metabolism to AMD pathology. Paraoxonase 1 (PON1) is an antioxidative protein involved in high density lipoprotein (HDL) function and was found to be associated with AMD. Here, we used Pon1(-/-) mice
Buin Adams et al.
Cardiovascular diabetology, 14, 94-94 (2015-07-29)
Acute hyperglycemia co-presenting with myocardial infarction (in diabetic and non-diabetic individuals) is often associated with a poor prognosis. Although acute hyperglycemia induces oxidative stress that can lead to dysregulation of the ubiquitin-proteasome system (UPS), it is unclear whether increased/decreased UPS
Peter B Schwarz et al.
The Journal of physiology, 592(16), 3597-3609 (2014-05-27)
Noradrenergic neurotransmission in the brainstem is closely coupled to changes in muscle activity across the sleep-wake cycle, and noradrenaline is considered to be a key excitatory neuromodulator that reinforces the arousal-related stimulus on motoneurons to drive movement. However, it is
Linde A Miles et al.
PloS one, 10(6), e0129103-e0129103 (2015-06-13)
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide
Min-Hui Yang et al.
Biochimica et biophysica acta, 1852(1), 166-174 (2014-12-03)
Our previous studies have shown that the 3' end of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is involved in colorectal cancer (CRC) cell proliferation and migration/invasion in vitro. The role and mechanism of MALAT1 in CRC metastasis in vivo
Sayani Dasgupta et al.
PloS one, 9(7), e103604-e103604 (2014-08-01)
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracellular peptides. However, bortezomib (an antitumor drug and
Vincenzo Carbone et al.
The Journal of biological chemistry, 290(35), 21690-21704 (2015-07-16)
One of the most critical events in the origins of cellular life was the development of lipid membranes. Archaea use isoprenoid chains linked via ether bonds to sn-glycerol 1-phosphate (G1P), whereas bacteria and eukaryotes use fatty acids attached via ester
Marwa E Elsherbiny et al.
Nutrients, 7(10), 8802-8817 (2015-10-28)
Arachidonic (AA) and docosahexaenoic acid (DHA) brain accretion is essential for brain development. The impact of DHA-rich maternal diets on offspring brain fatty acid composition has previously been studied up to the weanling stage; however, there has been no follow-up
Jing Du et al.
Journal of experimental botany, 65(14), 4051-4063 (2013-12-18)
After germination, cotyledons undertake the major role in supplying nutrients to the pre-photoautorophy angiosperm seedlings until they senesce. Like other senescence processes, cotyledon senescence is a programmed degenerative process. Nitric oxide can induce premature cotyledon senescence in Arabidopsis thaliana, yet
Claus Hedegaard et al.
FEBS open bio, 3, 411-420 (2013-11-20)
Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means of expressing a transgene specifically in neurons. The nucleotide sequence of the promoter displayed a high
Joanna M Woodcock et al.
Oncotarget, 6(16), 14522-14536 (2015-05-15)
14-3-3 proteins play a pivotal role in controlling cell proliferation and survival, two commonly dysregulated hallmarks of cancers. 14-3-3 protein expression is enhanced in many human cancers and correlates with more aggressive tumors and poor prognosis, suggesting a role for
Won-Sik Shin et al.
Cancer science, 104(8), 1120-1126 (2013-05-15)
Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer that is particularly prevalent in East Asian countries. Our previous expression profile analysis showed that the gene encoding protein tyrosine kinase 7 (PTK7) is upregulated in ESCC tissues.
Hoang Trong Phan et al.
PloS one, 9(6), e99347-e99347 (2014-06-11)
Fusion protein strategies are useful tools to enhance expression and to support the development of purification technologies. The capacity of fusion protein strategies to enhance expression was explored in tobacco leaves and seeds. C-terminal fusion of elastin-like polypeptides (ELP) to
Fiona B McDonald et al.
Experimental physiology, 100(8), 947-966 (2015-06-23)
What is the central question of this study? Chronic intermittent hypoxia (CIH) is a dominant feature of respiratory control disorders, which are common. We sought to examine the effects of exposure to CIH during neonatal development on respiratory muscle form
Yun Mou et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10714-10719 (2015-08-14)
Homodimers are the most common type of protein assembly in nature and have distinct features compared with heterodimers and higher order oligomers. Understanding homodimer interactions at the atomic level is critical both for elucidating their biological mechanisms of action and
Paola Castro-Garcia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1480-1492 (2015-02-01)
We studied potential changes in the subventricular zone (SVZ) stem cell niche of the senescence-accelerated mouse prone-8 (SAM-P8) aging model. Bromodeoxyuridine (BrdU) assays with longtime survival revealed a lower number of label-retaining stem cells in the SAM-P8 SVZ compared with
Hsiao-Li Wu et al.
Fertility and sterility, 103(4), 1098-1106 (2015-02-17)
To determine whether berberine (BBR), a naturally occurring plant-derived alkaloid, inhibits the proliferation of human uterine leiomyoma (UtLM) cells. Laboratory research. Laboratory. UtLM and normal human uterine smooth muscle (UtSMC) cell lines. Treatment with [1] BBR (10, 20, and 50
Sevim Akgül Celik et al.
Dimensions of critical care nursing : DCCN, 25(1), 11-14 (2006-02-28)
The use of isotonic sodium chloride on endotracheal suctioning is still commonly performed in intensive care units (ICUs). According to the studies, isotonic sodium chloride instillation may decrease oxygen saturation, increased intracranial pressure, arterial blood pressure, and cause cardiac dysrhythmias
Degang Wang et al.
Molecular medicine reports, 11(1), 175-181 (2014-10-24)
Preparations utilizing monoclonal antibodies against S100A4 provide useful tools for functional studies to investigate the clinical applications of the human S100A4 protein. In the present study, human S100A4 protein was expressed in Escherichia coli (E. coli) BL21 (DE3), successfully purified
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