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Matthew C Henn et al.
Journal of the American Heart Association, 4(8), e002016-e002016 (2015-08-26)
ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism. The renal outer medullary kidney potassium channel subunit, potassium inward rectifying (Kir)1.1, has been implicated as
Chao Zhen et al.
Journal of neuroimmunology, 280, 1-7 (2015-03-17)
Multiple sclerosis (MS) has been associated with a history of sub-optimal exposure to ultraviolet light, implicating vitamin D3 as a possible protective agent. We evaluated whether 1,25(OH)2D3 attenuates the progression of experimental autoimmune encephalomyelitis (EAE), and explored its potential mechanisms.
Monique Simons et al.
PloS one, 10(7), e0126023-e0126023 (2015-07-15)
The aim of the current study was to evaluate the effects of and adherence to an active video game promotion intervention on anthropometrics, sedentary screen time and consumption of sugar-sweetened beverages and snacks among non-active video gaming adolescents who primarily
Friederike Twele et al.
Neuropharmacology, 95, 234-242 (2015-04-04)
The AMPA receptor subtype of glutamate receptors, which mediates fast synaptic excitation, is of primary importance in initiating epileptiform discharges, so that AMPA receptor antagonists exert anti-seizure activity in diverse animal models of partial and generalized seizures. Recently, the first
César H Yokomizo et al.
Chemical research in toxicology, 28(6), 1167-1175 (2015-04-29)
The effect of four trichlorotelluro-dypnones, named compounds 1, 2, 3, and 4, on the bioenergetics of isolated rat liver mitochondria (RLM) and cells was investigated. In a dose-dependent manner, the studied organotelluranes promoted Ca(2+)-dependent mitochondrial swelling inhibited by cyclosporine A
K Nordengen et al.
Cerebral cortex (New York, N.Y. : 1991), 30(3), 1422-1435 (2019-09-11)
While a lot is known about classical, anterograde neurotransmission, less is known about the mechanisms and molecules involved in retrograde neurotransmission. Our hypothesis is that N-acetylaspartylglutamate (NAAG), the most abundant dipeptide in the brain, may act as a retrograde transmitter
Henrique Noronha et al.
Planta, 242(4), 909-920 (2015-05-27)
Two grapevine glucose-6-Pi plastidial transporters differently expressed in plant organs and in response to environmental and hormonal signals are characterized. They are involved in starch accumulation in berries and canes. In grapevine, starch accumulation in the trunk is important for
Lauren T Robertson et al.
The Journal of nutrition, 145(8), 1717-1727 (2015-06-05)
Short-term dietary restriction (DR) without malnutrition preconditions against surgical stress in rodents; however, the nutritional basis and underlying nutrient/energy-sensing pathways remain poorly understood. We investigated the relative contribution of protein restriction (PR) vs. calorie restriction (CR) to protection from renal
David Baur et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 1858-1871 (2015-02-06)
Tight coupling between Ca(2+) channels and the sensor for vesicular transmitter release at the presynaptic active zone (AZ) is crucial for high-fidelity synaptic transmission. It has been hypothesized that a switch from a loosely coupled to a tightly coupled transmission
Shixuan Wang et al.
PloS one, 9(5), e95630-e95630 (2014-05-24)
FPC (fibrocystin or polyductin) is a single transmembrane receptor-like protein, responsible for the human autosomal recessive polycystic kidney disease (ARPKD). It was recently proposed that FPC undergoes a Notch-like cleavage and subsequently the cleaved carboxy(C)-terminal fragment translocates to the nucleus.
Alexandra Colin et al.
Current biology : CB, 28(16), 2647-2656 (2018-08-14)
Coordination between actin filaments and microtubules is critical to complete important steps during cell division. For instance, cytoplasmic actin filament dynamics play an active role in the off-center positioning of the spindle during metaphase I in mouse oocytes [1-3] or
Shun-Fan Zhou et al.
The New phytologist, 208(1), 188-197 (2015-04-29)
Abscisic acid plays important roles in maintaining seed dormancy while gibberellins (GA) and other phytohormones antagonize ABA to promote germination. However, how ABA signaling is desensitized during the transition from dormancy to germination is still poorly understood. We functionally characterized
Sona Balentova et al.
Neurochemical research, 40(3), 501-513 (2014-12-10)
Ionizing radiation induces altered brain tissue homeostasis and can lead to morphological and functional deficits. In this study, adult male Wistar rats received whole-body exposure with fractionated doses of gamma rays (a total dose of 5 Gy) and were investigated
Moinecha Madi et al.
The Journal of membrane biology, 248(5), 903-908 (2015-03-20)
DNA electrotransfer is a successful technic for gene delivery. However, its use in clinical applications is limited since little is known about the mechanisms governing DNA electrotransfer in the complex environment occurring in a tissue. The objectives of this work
Hemant Kumar Rawat et al.
Antonie van Leeuwenhoek, 107(3), 799-811 (2015-01-07)
Owing to applications in the food and nutraceutical industries, inulinases, fructosyltransferases and sucrases have gained considerable attention in recent times. Twenty-five fungal strains were screened for production of these enzymes on three different media formulated using inulin-rich plant extracts prepared
Luiz G Maturana et al.
Brain and behavior, 3(4), 417-430 (2014-01-02)
The purpose of this study was to investigate the influence of implanting collagen with a supramolecular organization on peripheral nerve regeneration, using the sciatic nerve tubulization technique. For this purpose, adult female Sprague Dawley rats were divided into five groups:
M Yue et al.
Neurobiology of disease, 78, 172-195 (2015-04-04)
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase
Chun-Nun Chao et al.
Journal of translational medicine, 13, 29-29 (2015-01-28)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of aggressive B-cell non-Hodgkin lymphoma. About one-third of patients are either refractory to the treatment or experience relapse afterwards, pointing to the necessity of developing other effective therapies
Christian K Pfaller et al.
Journal of virology, 89(15), 7735-7747 (2015-05-15)
Defective interfering RNAs (DI-RNAs) of the viral genome can form during infections of negative-strand RNA viruses and outgrow full-length viral genomes, thereby modulating the severity and duration of infection. Here we document the frequent de novo generation of copy-back DI-RNAs
R Huang et al.
Applied and environmental microbiology, 80(23), 7212-7218 (2014-09-14)
Streptococcus gordonii is a commensal species of human oral flora. It initiates dental biofilm formation and provides binding sites for later colonizers to attach to and generate mature biofilm. Smoking is the second highest risk factor for periodontal disease, and
Daniel Sohmen et al.
Nature communications, 6, 6941-6941 (2015-04-24)
Ribosomal stalling is used to regulate gene expression and can occur in a species-specific manner. Stalling during translation of the MifM leader peptide regulates expression of the downstream membrane protein biogenesis factor YidC2 (YqjG) in Bacillus subtilis, but not in
Sen-Lin Ji et al.
International journal of medicinal mushrooms, 17(5), 435-442 (2015-06-18)
This study aimed to improve polysaccharide production by engineering the biosynthetic pathway in Ganoderma lucidum through the overexpression of the homologous UDP glucose pyrophosphorylase (UGP) gene. The effects of UGP gene overexpression on intracellular polysaccharide (IPS) content, extracellular polysaccharide (EPS)
Nageena Zahid et al.
Applied microbiology and biotechnology, 99(13), 5511-5521 (2015-05-16)
Gluconobacter oxydans is an industrially important bacterium owing to its regio- and enantio-selective incomplete oxidation of various sugars, alcohols, and polyols. The complete genome sequence is available, but it is still unknown how the organism adapts to highly osmotic sugar-rich
Michael J Lawrence et al.
The Journal of experimental biology, 218(Pt 13), 2124-2135 (2015-05-20)
Relative to the gills, the mechanisms by which the kidney contributes to ammonia and acid-base homeostasis in fish are poorly understood. Goldfish were exposed to a low pH environment (pH 4.0, 48 h), which induced a characteristic metabolic acidosis and an increase
Xiao-Li Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4804-4814 (2015-09-24)
Pathogenic mycobacteria transport virulence factors across their complex cell wall via a type VII secretion system (T7SS)/early secreted antigenic target-6 of kDa secretion system (ESX). ESX conserved component (Ecc) B, a core component of the T7SS architecture, is predicted to
Wendy L Imlach et al.
Molecular pharmacology, 88(3), 460-468 (2015-06-25)
In the spinal cord and periphery, adenosine inhibits neuronal activity through activation of the adenosine A1 receptor (A1R), resulting in antinociception and highlighting the potential of therapeutically targeting the receptor in the treatment of neuropathic pain. This study investigated the
Xiao-Dong Hu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 13989-14001 (2015-10-16)
Protein phosphatase-1 (PP1), anchored by regulatory or targeting proteins at excitatory glutamatergic synapses, controls the phosphorylation of postsynaptic substrates and regulates the neurotransmission and plasticity. Here, we found that spinophilin, an actin-binding protein that targets PP1 at postsynaptic density, served
Jennifer R Davies et al.
The European journal of neuroscience, 42(4), 2105-2113 (2015-06-05)
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by deletion or inactivation of paternally expressed imprinted genes on human chromosome 15q11-q13, the most recognised feature of which is hyperphagia. This is thought to arise as a consequence of abnormalities in
Nikita Ikon et al.
Biochemical and biophysical research communications, 464(2), 580-585 (2015-07-15)
The concentration and composition of cardiolipin (CL) in mitochondria are altered in age-related heart disease, Barth Syndrome, and other rare genetic disorders, resulting in mitochondrial dysfunction. To explore whether exogenous CL can be delivered to cells, CL was combined with
Katsuyoshi Fujimoto et al.
Journal of natural medicines, 68(3), 481-487 (2014-02-18)
Seven new acylated sucroses, mumeoses P-V, were isolated from the flower buds of Prunus mume, cultivated in Zhejiang province, China. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. Moreover, mumeoses C, D, and R, were
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