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Christina L Wilson et al.
Nanoscale, 7(44), 18477-18488 (2015-08-15)
Titanium dioxide (TiO2) nanoparticles are currently the second most produced engineered nanomaterial in the world with vast usage in consumer products leading to recurrent human exposure. Animal studies indicate significant nanoparticle accumulation in the brain while cellular toxicity studies demonstrate
Rimpy Dhingra et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(51), E5537-E5544 (2014-12-10)
Doxorubicin (DOX) is widely used for treating human cancers, but can induce heart failure through an undefined mechanism. Herein we describe a previously unidentified signaling pathway that couples DOX-induced mitochondrial respiratory chain defects and necrotic cell death to the BH3-only
I A Lyakhova et al.
Bulletin of experimental biology and medicine, 164(5), 666-672 (2018-03-27)
Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin and 7-phenylfascaplysin exhibited the best
Nina Vorobjeva et al.
Biochimica et biophysica acta. Molecular basis of disease, 1866(5), 165664-165664 (2020-01-12)
Neutrophils release neutrophil extracellular traps (NETs) in response to numerous pathogenic microbes as the last suicidal resource (NETosis) in the fight against infection. Apart from the host defense function, NETs play an essential role in the pathogenesis of various autoimmune
Lara Gibellini et al.
Frontiers in oncology, 8, 254-254 (2018-07-25)
Mitochondrial Lon protease (LonP1) is a multi-function enzyme that regulates mitochondrial functions in several human malignancies, including colorectal cancer (CRC). The mechanism(s) by which LonP1 contributes to colorectal carcinogenesis is not fully understood. We found that silencing LonP1 leads to
Deyu Chen et al.
Molecular genetics & genomic medicine, 8(5), e1199-e1199 (2020-03-13)
The m.14487T>C mutation is recognized as a diagnostic mutation of mitochondrial disease during the past 16 years, emerging evidence suggests that mutant loads of m.14487T>C and disease phenotype are not closely correlated. Immortalized lymphocytes were generated by coculturing the Epstein-Barr virus
Vikas Kumar et al.
Scientific reports, 9(1), 13170-13170 (2019-09-13)
We examined the hitherto unexplored role of mitochondrial transporters and iron metabolism in advancing metabolic and mitochondrial dysfunction in the heart during long term pressure overload. We also investigated the link between mitochondrial dysfunction and fluctuation in mitochondrial transporters associated
Hyoung Kyu Kim et al.
Marine drugs, 16(6) (2018-06-06)
Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome. We investigated the potential use of Ech A for inducing cardiomyocyte differentiation
Jemma Gatliff et al.
Cell death & disease, 8(6), e2896-e2896 (2017-06-24)
The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquitination via
Ryota Kikuchi et al.
Free radical biology & medicine, 134, 200-214 (2019-01-15)
The tumor microenvironment has previously been reported to be hypercapnic (as high as ~84 mmHg), although its effect on tumor cell behaviors is unknown. In this study, high CO2 levels, ranging from 5% to 15%, protected lung cancer cells from anticancer
Naho Nomura et al.
Scientific reports, 11(1), 1666-1666 (2021-01-20)
Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic roles in HSC characteristics throughout life, but its stage-specific roles in HSC self-renewal are unclear. To investigate the effects
Linyan Lv et al.
Frontiers in pharmacology, 12, 616803-616803 (2021-03-27)
Triptolide is widely used in the clinical treatment of various diseases. Side effects, including reproductive toxicity to male patients, limit its application. However, no detailed mechanisms or potential intervention targets have been reported. In this study, we show that triptolide
Su-Geun Lim et al.
Journal of immunology (Baltimore, Md. : 1950), 204(5), 1299-1309 (2020-01-26)
LETM1 domain-containing protein 1 (LETMD1), also known as HCCR-1, is a mitochondrial protein and is known to regulate p53 and STAT3 activities in cancer cells. In this study, we present, for the first time (to our knowledge), data indicating that
Phillippa J Carling et al.
Progress in neurobiology, 187, 101772-101772 (2020-02-15)
Mechanistic disease stratification will be crucial to develop a precision medicine approach for future disease modifying therapy in sporadic Parkinson's disease (sPD). Mitochondrial and lysosomal dysfunction are key mechanisms in the pathogenesis of sPD and therefore promising targets for therapeutic
Magdalena Bachmann et al.
Pharmacological research, 164, 105326-105326 (2020-12-19)
The two-pore potassium channel TASK-3 has been shown to localize to both the plasma membrane and the mitochondrial inner membrane. TASK-3 is highly expressed in melanoma and breast cancer cells and has been proposed to promote tumor formation. Here we
Alessandro Rimessi et al.
Science advances, 6(19), eaax9093-eaax9093 (2020-06-05)
Mitochondria physically associate with the endoplasmic reticulum to coordinate interorganelle calcium transfer and regulate fundamental cellular processes, including inflammation. Deregulated endoplasmic reticulum-mitochondria cross-talk can occur in cystic fibrosis, contributing to hyperinflammation and disease progression. We demonstrate that Pseudomonas aeruginosa infection
Amy H Zhao et al.
The Journal of biological chemistry, 291(4), 1591-1603 (2015-12-03)
Function of the mammalian translocator protein (TSPO; previously known as the peripheral benzodiazepine receptor) remains unclear because its presumed role in steroidogenesis and mitochondrial permeability transition established using pharmacological methods has been refuted in recent genetic studies. Protoporphyrin IX (PPIX)
Emily L Yarosz et al.
Journal of immunology (Baltimore, Md. : 1950), 204(7), 1708-1713 (2020-03-04)
Iron has long been established as a critical mediator of T cell development and proliferation. However, the mechanisms by which iron controls CD4 T cell activation and expansion remain poorly understood. In this study, we show that stimulation of CD4
Liang Yang et al.
Cellular and molecular life sciences : CMLS, 72(13), 2585-2598 (2015-02-25)
Heteroplasmic cells, harboring both mutant and normal mitochondrial DNAs (mtDNAs), must accumulate mutations to a threshold level before respiratory activity is affected. This phenomenon has led to the hypothesis of mtDNA complementation by inter-mitochondrial content mixing. The precise mechanisms of
T Touvier et al.
Cell death & disease, 6, e1663-e1663 (2015-02-27)
Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models generated so
Peter I Joyce et al.
Human molecular genetics, 25(2), 291-307 (2015-11-26)
Zinc finger motifs are distributed amongst many eukaryotic protein families, directing nucleic acid-protein and protein-protein interactions. Zinc finger protein 106 (ZFP106) has previously been associated with roles in immune response, muscle differentiation, testes development and DNA damage, although little is
Sara Fatima Faqar-Uz-Zaman et al.
Cancer letters, 412, 131-142 (2017-09-28)
BH3 mimetics are a promising new class of anticancer agents that inhibit antiapoptotic BCL-2 proteins. Here, we report that BH3 mimetics selectively targeting BCL-x
Cecilia Mancini et al.
Neurobiology of disease, 124, 14-28 (2018-11-06)
Spinocerebellar ataxia 28 is an autosomal dominant neurodegenerative disorder caused by missense mutations affecting the proteolytic domain of AFG3L2, a major component of the mitochondrial m-AAA protease. However, little is known of the underlying pathogenetic mechanisms or how to treat
Kohsuke Kanekura et al.
Science signaling, 8(382), ra62-ra62 (2015-06-25)
The endoplasmic reticulum (ER) has emerged as a critical regulator of cell survival. IRE1 is a transmembrane protein with kinase and RNase activities that is localized to the ER and that promotes resistance to ER stress. We showed a mechanism
Takuma Yoshizumi et al.
Nature communications, 5, 4713-4713 (2014-08-21)
Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited to the mitochondrial membrane, and depends on the mitochondrial inner membrane potential (Δψm). Here we examine the physiological relevance of
Yujie Zhu et al.
Biomedical optics express, 8(11), 4965-4973 (2017-12-01)
The research of mitochondrial dysfunction is of great importance and implicated in a range of neurodegenerative diseases. Traditionally, to investigate mitochondrial dynamics and functions, mitochondria are usually stimulated indirectly by treating cells with exogenous chemicals like oxidative agents. Such treatment
Shuai Wang et al.
Neuroscience letters, 706, 7-11 (2019-04-28)
It has been recognized that the use of ropivacaine may cause neurotoxicity and cardiotoxicity in the perioperative period of local anesthesia effects. However, the molecular mechanism of ropivacaine in causing the neurotoxicity remains unclear. Cell viability and cell apoptosis were
Pelin A Golforoush et al.
Scientific reports, 10(1), 12060-12060 (2020-07-23)
Given the poor track record to date of animal models for creating cardioprotective drugs, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been proposed as a therapeutically relevant human platform to guide target validation and cardiac drug development. Mitogen-Activated Protein Kinase
Wuzheng Zhu et al.
Cell death & disease, 9(8), 837-837 (2018-08-08)
Mitochondrial dysfunction and excessive mitochondrial reactive oxygen species (ROS) are fundamental contributors to endothelial injury in diabetic states. Mesenchymal stem cells (MSCs) have exhibited an extraordinary cytoprotective effect that extends to the modulation of mitochondrial homeostasis. However, the underlying mechanisms
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