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Naho Nomura et al.
Scientific reports, 11(1), 1666-1666 (2021-01-20)
Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic roles in HSC characteristics throughout life, but its stage-specific roles in HSC self-renewal are unclear. To investigate the effects
Shuai Wang et al.
Neuroscience letters, 706, 7-11 (2019-04-28)
It has been recognized that the use of ropivacaine may cause neurotoxicity and cardiotoxicity in the perioperative period of local anesthesia effects. However, the molecular mechanism of ropivacaine in causing the neurotoxicity remains unclear. Cell viability and cell apoptosis were
Ryota Kikuchi et al.
Free radical biology & medicine, 134, 200-214 (2019-01-15)
The tumor microenvironment has previously been reported to be hypercapnic (as high as ~84 mmHg), although its effect on tumor cell behaviors is unknown. In this study, high CO2 levels, ranging from 5% to 15%, protected lung cancer cells from anticancer
Zina Sarif et al.
Molecular carcinogenesis, 59(11), 1256-1268 (2020-09-05)
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively in cancer cells. For melanoma, the targeting of TRAIL signaling appears highly attractive, due to pronounced TRAIL receptor expression in tumor tissue. However, mechanisms of TRAIL resistance observed in melanoma cells may limit
Victoria C Young et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(8) (2021-02-19)
Cellular survival requires the ion gradients built by the Na+/K+ pump, an ATPase that alternates between two major conformations (E1 and E2). Here we use state-specific engineered-disulfide cross-linking to demonstrate that transmembrane segment 2 (M2) of the pump's α-subunit moves
Elena A Matveeva et al.
Biology open, 4(10), 1290-1297 (2015-09-16)
In this study we show that binding of mitochondria to vimentin intermediate filaments (VIF) is regulated by GTPase Rac1. The activation of Rac1 leads to a redoubling of mitochondrial motility in murine fibroblasts. Using double-mutants Rac1(G12V, F37L) and Rac1(G12V, Y40H)
Fan Zhang et al.
Molecular biology of the cell, 31(14), 1538-1549 (2020-05-07)
A metabolic transition from glycolysis to oxidative phosphorylation is often associated with differentiation of many types of stem cells. However, the link between mitochondrial respiration and stem cells' behavior is not fully understood. We genetically disrupted electron transport chain (ETC)
Wuzheng Zhu et al.
Cell death & disease, 9(8), 837-837 (2018-08-08)
Mitochondrial dysfunction and excessive mitochondrial reactive oxygen species (ROS) are fundamental contributors to endothelial injury in diabetic states. Mesenchymal stem cells (MSCs) have exhibited an extraordinary cytoprotective effect that extends to the modulation of mitochondrial homeostasis. However, the underlying mechanisms
Christina L Wilson et al.
Nanoscale, 7(44), 18477-18488 (2015-08-15)
Titanium dioxide (TiO2) nanoparticles are currently the second most produced engineered nanomaterial in the world with vast usage in consumer products leading to recurrent human exposure. Animal studies indicate significant nanoparticle accumulation in the brain while cellular toxicity studies demonstrate
Andrey V Kuznetsov et al.
Biochimica et biophysica acta, 1853(2), 276-284 (2014-12-03)
Dysfunction of cardiac energy metabolism plays a critical role in many cardiac diseases, including heart failure, myocardial infarction and ischemia-reperfusion injury and organ transplantation. The characteristics of these diseases can be elucidated in vivo, though animal-free in vitro experiments, with
Sara Fatima Faqar-Uz-Zaman et al.
Cancer letters, 412, 131-142 (2017-09-28)
BH3 mimetics are a promising new class of anticancer agents that inhibit antiapoptotic BCL-2 proteins. Here, we report that BH3 mimetics selectively targeting BCL-x
Kyeong-Ah Jung et al.
Antioxidants & redox signaling, 27(13), 945-961 (2017-04-07)
The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NFE2L2/NRF2) pathway contributes to the environmental resistance of cancers by enhancing the antioxidant capacity. Here, we explored the potential connection between NFE2L2/NRF2 and mitochondrial function in cancers. Global miRNA expression analysis of HT29
Yujie Zhu et al.
Biomedical optics express, 8(11), 4965-4973 (2017-12-01)
The research of mitochondrial dysfunction is of great importance and implicated in a range of neurodegenerative diseases. Traditionally, to investigate mitochondrial dynamics and functions, mitochondria are usually stimulated indirectly by treating cells with exogenous chemicals like oxidative agents. Such treatment
Kohsuke Kanekura et al.
Science signaling, 8(382), ra62-ra62 (2015-06-25)
The endoplasmic reticulum (ER) has emerged as a critical regulator of cell survival. IRE1 is a transmembrane protein with kinase and RNase activities that is localized to the ER and that promotes resistance to ER stress. We showed a mechanism
Takuma Yoshizumi et al.
Nature communications, 5, 4713-4713 (2014-08-21)
Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited to the mitochondrial membrane, and depends on the mitochondrial inner membrane potential (Δψm). Here we examine the physiological relevance of
Csaba Konrad et al.
Molecular neurodegeneration, 12(1), 76-76 (2017-10-27)
The objective of this study was to investigate cellular bioenergetics in primary skin fibroblasts derived from patients with amyotrophic lateral sclerosis (ALS) and to determine if they can be used as classifiers for patient stratification. We assembled a collection of
Hye-Young Min et al.
Cell death & disease, 10(11), 810-810 (2019-10-28)
Mitochondria play a pivotal role in cancer bioenergetics and are considered a potential target for anticancer therapy. Considering the limited efficacy and toxicity of currently available mitochondria-targeting agents, it is necessary to develop effective mitochondria-targeting anticancer drugs. By screening a
Kimberli J Kamer et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(34), E7960-E7969 (2018-08-08)
The mitochondrial uniporter is a Ca2+-activated Ca2+ channel complex that displays exceptionally high conductance and selectivity. Here, we report cellular metal toxicity screens highlighting the uniporter's role in Mn2+ toxicity. Cells lacking the pore-forming uniporter subunit, MCU, are more resistant
Ling Chien et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(9 Pt B), 3001-3012 (2018-06-19)
Due to the inhibitory microenvironment and reduced intrinsic growth capacity of neurons, neuronal regeneration of central nervous system remains challenging. Neurons are highly energy demanding and require sufficient mitochondria to support cellular activities. In response to stimuli, mitochondria undergo fusion/fission
Beilei Liu et al.
Journal of biomedical materials research. Part A, 107(6), 1132-1142 (2019-01-01)
Compositions of resin composite exhibit cytotoxicity, especially Triethylene-glycol-dimethacrylate (TEGDMA), yet the underlying mechanisms and its relationship with filler content are poorly understood. Here, specimens of five composites (VITA LC, VITA ZETA, Z350, Filtek P60, and AP-X), containing different filler size
Markus Hartl et al.
Molecular systems biology, 13(10), 949-949 (2017-10-25)
Histone deacetylases have central functions in regulating stress defenses and development in plants. However, the knowledge about the deacetylase functions is largely limited to histones, although these enzymes were found in diverse subcellular compartments. In this study, we determined the
Angela C Court et al.
EMBO reports, 21(2), e48052-e48052 (2020-01-28)
Mesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune-mediated diseases. They exert immunoregulatory and tissue-restoring effects. MSC-mediated transfer of mitochondria (MitoT) has been demonstrated to rescue target organs from tissue damage, yet the mechanism remains to
Angela Tomasovic et al.
Nature communications, 11(1), 1733-1733 (2020-04-09)
Dysregulation of extracellular signal-regulated kinases (ERK1/2) is linked to several diseases including heart failure, genetic syndromes and cancer. Inhibition of ERK1/2, however, can cause severe cardiac side-effects, precluding its wide therapeutic application. ERKT188-autophosphorylation was identified to cause pathological cardiac hypertrophy.
Artyom Y Baev et al.
Journal of bioenergetics and biomembranes, 49(1), 49-55 (2016-02-19)
Inorganic polyphosphate (polyP) is a biopolymer of phosphoanhydride-linked orthophosphate residues. PolyP is involved in multiple cellular processes including mitochondrial metabolism and cell death. We used artificial membranes and isolated mitochondria to investigate the role of the polyP in mitochondrial ion
Qing Yu et al.
Journal of Alzheimer's disease : JAD, 59(1), 223-239 (2017-06-10)
Loss of synapse and synaptic dysfunction contribute importantly to cognitive impairment in Alzheimer's disease (AD). Mitochondrial dysfunction and oxidative stress are early pathological features in AD-affected brain. However, the effect of AD mitochondria on synaptogenesis remains to be determined. Using
Sebastián Fuentes-Retamal et al.
Cells, 9(2) (2020-02-15)
The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, 10-((2,5-dihydroxybenzoyl)oxy)decyl) triphenylphosphonium bromide (GA-TPP+C10), with a hydroquinone scaffold that selectively
Jolanta Janiszewska et al.
PloS one, 11(11), e0165704-e0165704 (2016-11-11)
Glioblastomas are the most common malignant primary brain tumours in adults and one of the most aggressive and difficult-to-treat cancers. No effective treatment exits actually for this tumour and new therapeutic approaches are needed for this disease. One possible innovative
E Sorato et al.
Free radical biology & medicine, 75, 40-47 (2014-07-16)
Although mitochondrial dysfunction and oxidative stress have been proposed to play a crucial role in several types of muscular dystrophy (MD), whether a causal link between these two alterations exists remains an open question. We have documented that mitochondrial dysfunction
Wenqing Zhou et al.
Journal of cell science, 133(17) (2020-08-14)
Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates neutrophil homeostasis and chemotaxis in vivo Mfn2-deficient neutrophils are released from the
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