Merck
  • ホーム
  • 検索結果
  • Increased cortisol awakening response was associated with time to recurrence of major depressive disorder.

Increased cortisol awakening response was associated with time to recurrence of major depressive disorder.

Psychoneuroendocrinology (2014-09-03)
Florian Hardeveld, Jan Spijker, Sophie A Vreeburg, Ron De Graaf, Sanne M Hendriks, Carmilla M M Licht, Willem A Nolen, Brenda W J H Penninx, Aartjan T F Beekman
要旨

Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening cortisol) predict time to recurrence in remitted subjects with a history of MDD and whether childhood trauma and life events interact with HPA-axis parameters in increasing the risk for recurrence. Data were derived from 549 subjects with a lifetime diagnosis of MDD in remission for at least six months preceding the baseline assessment of the Netherlands Study of Depression and Anxiety (NESDA). Subjects were followed up with two interviews over the course of four years to assess recurrence. DSM-IV based diagnostic interviews were used to assess time to recurrence of MDD. Seven salivary cortisol samples collected at baseline with information on CAR, evening cortisol and the DST. Hazard ratios were calculated using Cox regression analysis, adjusted for covariates. A higher CAR was associated with time to recurrence of MDD (HR=1.03, 95%CI 1.003-1.060, p=0.03) whereas evening cortisol and DST were not. No interactions between HPA-axis parameters and stress-related factors were found. Our data support previous studies reporting that subjects with a higher CAR are more vulnerable to recurrence of MDD.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
ヒドロコルチゾン, BioReagent, suitable for cell culture
Sigma-Aldrich
ヒドロコルチゾン, ≥98% (HPLC)
Sigma-Aldrich
ヒドロコルチゾン, γ-irradiated, powder, BioXtra, suitable for cell culture
Supelco
ヒドロコルチゾン, Pharmaceutical Secondary Standard; Certified Reference Material
ヒドロコルチゾン, European Pharmacopoeia (EP) Reference Standard
USP
ヒドロコルチゾン, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
ヒドロコルチゾン, meets USP testing specifications
ヒドロコルチゾン, European Pharmacopoeia (EP) Reference Standard
Supelco
ヒドロコルチゾン, VETRANAL®, analytical standard
ヒドロコルチゾン, British Pharmacopoeia (BP) Assay Standard