Search Within
lichropur® bases for hplc and lc-ms
Applied Filters:
Keyword:'lichropur® bases for hplc and lc-ms'
Showing 1-30 of 180 results for "lichropur® bases for hplc and lc-ms" within Papers
A rapid screening LC?MS/MS method based on conventional HPLC pumps for the analysis of low molecular weight xenobiotics: application to doping control analysis
Mazzarino M, et al.
Drug Testing and Analysis, 2(7), 311-322 (2010)
Sujata Choudhury et al.
Mutation research, 751-752, 15-23 (2013-10-12)
ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) play a role in the pathogenesis of colon cancer. Upon oxidation, PUFAs generate α,β-unsaturated aldehydes or enals, such as acrolein (Acr) and (E)-4-hydroxy-2-nonenal (HNE), which can form cyclic adducts of deoxyguanosine (Acr-dG and
Xiyue Zhao et al.
Acta pharmaceutica Sinica. B, 9(5), 1050-1060 (2019-10-28)
Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma (HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report
Jin-Zhong Xu et al.
Journal of separation science, 32(23-24), 4020-4024 (2010-01-13)
A method for the determination and confirmation of amitraz and its degradation product 2,4-dimethylaniline (2,4-DMA) in honey is reported. Determination of the two compounds was based on HPLC with UV detection and MS/MS (LC-MS/MS) after a liquid-liquid extraction with hexane
H J Chen et al.
Chemical research in toxicology, 12(12), 1119-1126 (1999-12-22)
Exocyclic DNA adducts have been reported to derive from various exogenous as well as endogenous sources, such as lipid peroxidation. Among them, 1,N(6)-ethenoadenine (epsilonAde) has previously been detected in tissue DNA of untreated rodents and humans by an immunoaffinity/(32)P-postlabeling method.
Lawrence R Levinson et al.
Journal of food science, 76(4), C568-C575 (2012-03-16)
The multitude of food recalls in 2007 clearly demonstrated that total nitrogen-content (ΣN) determination by means of near-infrared spectroscopy (NIRS) and Kjeldahl-based measurements can be deceived, and should no longer be regarded as a complete quality assurance program for nutritive-protein
Nianbai Fang et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 488-497 (2014-10-12)
High-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are generally accepted as the preferred techniques for detecting and quantitating analytes of interest in biological matrices on the basis of the rule that one chemical compound yields one LC-peak
Mallikarjun Narayanam et al.
Journal of pharmaceutical and biomedical analysis, 111, 190-203 (2015-04-19)
Forced degradation studies on cilazapril were carried out according to ICH and WHO guidelines. Significant degradation of the drug was observed in acid and base conditions, resulting primarily in cilazaprilat. In neutral condition, five degradation products were formed, while under
Michael Kagan et al.
Journal of combinatorial chemistry, 11(4), 704-719 (2009-05-23)
A 23-member library of pyrrolobenzodiazepine derivatives with vasopressin agonist activity was purified on a 100-mg per injection scale using normal-phase (NP) automated mass-directed HPLC. Analytical NP APCI-LC/MS on an experimental monolith silica CN column utilizing gradients of methanol in ethoxynonafluorobutane
Ilgaz Akata et al.
Toxicon : official journal of the International Society on Toxinology, 187, 29-34 (2020-09-01)
Amatoxins, most of which are hepatotoxic, can cause fatal intoxication. While mushrooms in the amatoxin-containing Galerina genus are rare, they can poison humans and animals worldwide. Few studies have profiled the toxicity of Galerina marginata. In addition, many studies indicate
T W Chan et al.
Analytical chemistry, 72(6), 1281-1287 (2000-03-31)
An LC/MS-based method is established for the differentiation and authentication of specimens and commercial samples of Panax ginseng (Oriental ginseng) and Panax quinquefolius (American ginseng). This method is based on the separation of ginsenosides present in the ginseng methanolic extracts
Joachim Blanz et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 1-10 (2015-03-24)
LC-MS based drug metabolism studies are effective in the optimization stage of drug discovery for rapid partial structure identification of metabolites. However, these studies usually do not provide unambiguous structural characterization of all metabolites, due to the limitations of MS-based
Robert J Goldschmidt et al.
Journal of AOAC International, 96(2), 265-275 (2013-06-19)
A single-laboratory validation was performed for a method that determines pyridoxine, one of the B6 vitamers, in dietary supplements using LC and UV, fluorescence, or MS detection. The method was adapted for use with either HPLC or ultra-performance LC (UPLC).
Alexander V Gorshkov et al.
Analytical chemistry, 78(22), 7770-7777 (2006-11-16)
An approach to sequence-dependent retention time prediction of peptides based on the concept of liquid chromatography at critical conditions (LCCC) is presented. Within the LCCC approach applied to biopolymers (BioLCCC), the specific retention time corresponds to a particular sequence. In
I H Wang et al.
Journal of chromatography. A, 864(2), 271-281 (2000-02-11)
N-Octyl bicycloheptene dicarboximide (MGK 264) has exo and endo diastereomers. Each structure has a chiral center at the nitrogen side chain. Enantioselective separation of MGK 264 was achieved by normal-phase high-performance liquid chromatography (HPLC) using cellulose-based Chiralcel OD column with
Andrew V Grassetti et al.
Analytical and bioanalytical chemistry, 409(19), 4615-4625 (2017-05-31)
Technological advances in liquid chromatography and tandem mass spectrometry (LC-MS/MS) have enabled comprehensive analyses of proteins and their post-translational modifications from cell culture and tissue samples. However, sample complexity necessitates offline prefractionation via a chromatographic method that is orthogonal to
Peixi Zhu et al.
Journal of pharmaceutical and biomedical analysis, 107, 437-443 (2015-02-11)
A simple and sensitive method was developed for characterization of two impurities from commercial bendazac lysine eye drops, by using liquid chromatography combined with electrospray ionization and QTOF mass analyzer (LC-ESI-QTOF MS/MS). A known impurity was characterized rapidly by comparison
Zengliu Su et al.
Clinica chimica acta; international journal of clinical chemistry, 417, 62-66 (2012-12-26)
The circulating form of vitamin D, 25-Hydroxyvitamin D (25-OHD), is commonly measured in clinical labs to evaluate vitamin D status of an individual. Vitamin D exists in 2 major forms: vitamin D3 and D2. Current methodologies for 25-OHD testing include
Deepika Singh et al.
Molecules (Basel, Switzerland), 24(4) (2019-02-20)
Leea indica (Vitaceae) is a Southeast Asian medicinal plant. In this study, an ethyl acetate fraction of L. indica leaves was studied for its phytoconstituents using high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-microTOF-Q-MS/MS) analysis. A total of 31 compounds of different
Hong Wang et al.
Methods in molecular biology (Clifton, N.J.), 564, 227-242 (2009-06-23)
Electrospray ionization mass spectrometry (ESI-MS) is an efficient soft ionization procedure for macro biomolecules. However, it is a rather delicate process to produce charged molecules for mass-to-charge ratio (m/z) based measurement. In this chapter, the mechanism of ESI is briefly
Thomas W Moy et al.
Journal of chromatographic science, 41(7), 343-349 (2003-08-12)
A multiresidue pesticide methodology is studied and results for acidics are reported here, with base/neutral to follow. This work studies a literature procedure as a possible general approach to many pesticides and potentially other analytes that are considered to be
Erik Hanff et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 44-52 (2014-09-23)
A specific, sensitive and fast LC-MS/MS method with positive electrospray ionization for the quantitative determination of nitrite in human plasma is reported. Added [(15)N]nitrite served as the internal standard (IS). Endogenous nitrite and IS were converted to their S-nitrosoglutathione (GSNO)
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing.
Alexander Fauland et al.
Journal of lipid research, 52(12), 2314-2322 (2011-10-01)
This work aims to combine chromatographic retention, high mass resolution and accuracy, MS/MS spectra, and a package for automated identification and quantitation of lipid species in one platform for lipidomic analysis. The instrumental setup elaborated comprises reversed-phase HPLC coupled to
M Nishikawa et al.
Forensic science international, 66(3), 149-158 (1994-06-10)
The method for simultaneous determination of cocaine and its four metabolites (benzoylecgonine, ecgonine methyl ester, ecgonine and norcocaine) in urine by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS) was studied. The mass spectra showed the quasi-molecular ions, [M+H]+ as the
Sulabha Argade et al.
BJU international, 111(5), 811-819 (2013-02-21)
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The nucleotides associated with Tamm-Horsfall protein (THP) identified in this study are 2'(3') isomers, which are uncommon and very little is known about their biochemical pathway and role in
Francisco Javier Leyva-Jiménez et al.
Food research international (Ottawa, Ont.), 109, 213-222 (2018-05-29)
The extraction of bioactive compounds from Lippia citriodora leaves (Lc) has been evaluated by comparison between Pressurized Liquid Extraction (PLE) and conventional extrations combined with HPLC-ESI-TOF-MS in order to maximize recovery of phytochemicals and to know the efficiency of both
Yu Huang et al.
Analytical chemistry, 83(21), 8222-8229 (2011-09-20)
Microfluidic chip-based hydrophilic interaction chromatography (HILIC) is a useful separation system for liquid chromatography-mass spectrometry (LC-MS) in compositional profiling of heparan sulfate (HS) oligosaccharides; however, ions observed using HILIC LC-MS are low in charge. Tandem MS of HS oligosaccharide ions
Min Li et al.
Biochemical and biophysical research communications, 312(2), 316-322 (2003-11-26)
An HPLC assay method and an LC-MS method were used to study the Udenfriend reaction and its variations by using phenylalanine as the hydroxylation substrate. The results indicate that (1). citric acid can replace EDTA as the promoter for the
Pei Chen
Journal of AOAC International, 89(3), 612-618 (2006-06-24)
A new, rapid, and reproducible reversed-phased liquid chromatography (LC) method with ultraviolet (UV) absorption and/or mass spectrometry (MS) detection has been developed and validated for quantitation of cichoric acid, a major constituent of Echinacea spp. The method involves the use
Page 1 of 6