BRCC3
BRCA1/BRCA2-containing complex, subunit 3
동의어:
BRCC36, C6.1A, CXorf53
종:
Human BRCC3 (79184), Mouse Brcc3 (210766), Rat Brcc3 (316794), sheep BRCC3 (101114756), domestic cat BRCC3 (101096553), domestic guinea pig Brcc3 (100719736), dog BRCC3 (612642), cow BRCC3 (519513), chicken BRCC3 (422201), naked mole-rat Brcc3 (101719523)
UniProtKB ID:
Clone ID:
- Human(79184) Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
- Mouse(210766) BRCA1/BRCA2-containing complex, subunit 3
- Rat(316794) BRCA1/BRCA2-containing complex, subunit 3
- sheep(101114756) BRCA1/BRCA2-containing complex, subunit 3
- domestic cat(101096553) BRCA1/BRCA2-containing complex, subunit 3
- domestic guinea pig(100719736) BRCA1/BRCA2-containing complex, subunit 3
- dog(612642) BRCA1/BRCA2-containing complex, subunit 3
- cow(519513) BRCA1/BRCA2-containing complex, subunit 3
- chicken(422201) BRCA1/BRCA2-containing complex, subunit 3
- naked mole-rat(101719523) BRCA1/BRCA2-containing complex, subunit 3
- Horse(100062237) BRCA1/BRCA2-containing complex, subunit 3
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Antibodies
제품 번호
설명
종별 반응성
응용분야
Anti-BRCC3 Antibody, clone 2M19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
human, monkey, mouse
응용분야
affinity binding assay
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
Anti-BRCC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
종별 반응성
human
응용분야
immunofluorescence
esiRNA
제품 번호
설명
종