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Merck

DNMT3B

DNA (cytosine-5-)-methyltransferase 3 beta

동의어:
ICF, ICF1, M.HsaIIIB
:
UniProtKB ID:
Clone ID:
  • Human(1789) Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
  • Mouse(13436) DNA methyltransferase 3B
  • Rat(444985) DNA (cytosine-5-)-methyltransferase 3 beta
  • domestic guinea pig(100731772) DNA (cytosine-5-)-methyltransferase 3 beta
  • naked mole-rat(101725788) DNA (cytosine-5-)-methyltransferase 3 beta
  • dog(100685634) DNA (cytosine-5-)-methyltransferase 3 beta
  • Horse(100053900) DNA (cytosine-5-)-methyltransferase 3 beta
  • domestic cat(101092926) DNA (cytosine-5-)-methyltransferase 3 beta
  • cow(353354) DNA (cytosine-5-)-methyltransferase 3 beta
  • Domestic Rabbit(100349823) DNA (cytosine-5-)-methyltransferase 3 beta
  • sheep(100500777) DNA (cytosine-5-)-methyltransferase 3 beta
  • Zebrafish(321084) DNA (cytosine-5-)-methyltransferase 3 beta
  • chicken(419287) DNA (cytosine-5-)-methyltransferase 3 beta

Custom & Knockdown Gene Products

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-Dnmt3b Antibody, clone D3B2-2C1, clone D3B2-2C1, from rat,
종별 반응성
human
응용분야
immunoprecipitation (IP)
western blot
Anti-DNMT3B antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human
응용분야
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-DNMT3B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry

western blot
Anti-DNMT3B Antibody, clone 2N12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
human, monkey
응용분야
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-DNMT3B antibody produced in rabbit, affinity isolated antibody,
종별 반응성
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
응용분야
western blot

Small Molecule - Inhibitor

제품 번호
설명
5-Azacytidine, ≥98% (HPLC),
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human DNMT3B,
human