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Merck

MAP2K1

mitogen-activated protein kinase kinase 1

동의어:
CFC3, MAPKK1, MEK1, MKK1, PRKMK1
:
UniProtKB ID:
Clone ID:
  • Human(5604) Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
  • Mouse(26395) mitogen-activated protein kinase kinase 1
  • Rat(170851) mitogen activated protein kinase kinase 1
  • domestic guinea pig(100712888) mitogen-activated protein kinase kinase 1
  • dog(478347) mitogen-activated protein kinase kinase 1
  • Horse(100065996) mitogen-activated protein kinase kinase 1
  • domestic cat(101081387) mitogen-activated protein kinase kinase 1
  • chicken(415549) mitogen-activated protein kinase kinase 1
  • naked mole-rat(101715628) mitogen-activated protein kinase kinase 1
  • cow(533199) mitogen-activated protein kinase kinase 1
  • Domestic Rabbit(100009316) mitogen-activated protein kinase kinase 1
  • sheep(101123635) mitogen-activated protein kinase kinase 1
  • Zebrafish(406728) mitogen-activated protein kinase kinase 1

Custom & Knockdown Gene Products

ELISA

제품 번호
설명
Phosphotyrosine MAP2K1 ELISA Kit, ,
human

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-MAP2K1 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot
Anti-Phospho-MAP2K1-pS221 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-Phospho-MAP2K1-S217/MAP2K2-S221 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot
Anti-Phospho-MAP2K1-T286 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-MEK1 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunohistochemistry
western blot

Small Molecule - Inhibitor

제품 번호
설명
U0126, U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.,
human
U0126 ethanolate, ≥98% (HPLC), powder,
human
PD184352, ≥98% (HPLC),
human
PD 98,059, solid,
human

Proteins

제품 번호
설명
MEK1 Protein, inactive, 50 g, Unactive, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.,
human
MEK1 Protein, active, 10 µg, Active, N-terminal GST & C-terminal His6-tagged, recombinant full-length human MEK1, for use in Kinase Assays.,
human
MEK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
mouse

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human MAP2K1,
human
MISSION® esiRNA, targeting mouse Map2k1,
mouse