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Merck

PRKCA

protein kinase C, alpha

동의어:
AAG6, PKC-alpha, PKCA, PRKACA
:
UniProtKB ID:
Clone ID:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

Custom & Knockdown Gene Products

Small Molecule - Activator

제품 번호
설명
PKC Lipid Activator, ,
human

Small Molecule - Agonist

제품 번호
설명
Oleic acid, ≥99% (GC),
human

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-Phospho-PKC (pan) (zeta)-T410 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-Phospho-PKCalpha-S319 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-Phospho-PKCalpha-S226 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-Phospho-PKC alpha-S657/Y658 antibody produced in rabbit, ,
종별 반응성
human, mouse
응용분야
western blot
Anti-Phospho-PKC alpha-T638 antibody produced in rabbit, ,
종별 반응성
human
응용분야
western blot

Small Molecule - Inhibitor

제품 번호
설명
1-Oleoyl-2-acetyl-sn-glycerol, ≥97% (TLC), oil,
human
D-Sphingosine, synthetic,
rat
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
rat, human
(S)-(+)-Camptothecin, ≥90% (HPLC), powder,
rat, mouse, human
Bisindolylmaleimide IV, ≥98% (TLC), solid,
human, rat

Proteins

제품 번호
설명
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
human
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting mouse Prkca,
mouse
MISSION® esiRNA, targeting human PRKCA,
human

Small Molecule - Substrate

제품 번호
설명
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
human
PKC Substrate Cocktail, ,
human