PYGL
phosphorylase, glycogen, liver
동의어:
GSD6
종:
Human PYGL (5836), Mouse Pygl (110095), Rat Pygl (64035), sheep PYGL (554320), chicken PYGL (378909), Horse PYGL (100066726), Zebrafish pygl (493916), naked mole-rat Pygl (101723998), cow PYGL (505472), dog PYGL (403738) ...더
UniProtKB ID:
Clone ID:
- Human(5836) Summary: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
- Mouse(110095) liver glycogen phosphorylase
- Rat(64035) phosphorylase, glycogen, liver
- sheep(554320) phosphorylase, glycogen, liver
- chicken(378909) phosphorylase, glycogen, liver
- Horse(100066726) phosphorylase, glycogen, liver
- Zebrafish(493916) phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
- naked mole-rat(101723998) phosphorylase, glycogen, liver
- cow(505472) phosphorylase, glycogen, liver
- dog(403738) phosphorylase, glycogen, liver
- domestic cat(101089364) phosphorylase, glycogen, liver
- domestic guinea pig(100721433) phosphorylase, glycogen, liver
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Antibodies
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종별 반응성
응용분야
Anti-PYGL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
western blot
Anti-PYGL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PYGL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
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esiRNA
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