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440744

Sigma-Aldrich

Polycaprolactone

greener alternative

average Mn 80,000

동의어(들):

2-Oxepanone homopolymer, 6-Caprolactone polymer

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크기 선택

5 G
₩107,184
250 G
₩292,016
500 G
₩469,438

₩107,184

재고 있음세부사항

벌크 견적 요청
모든 사진(5)

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5 G
₩107,184
250 G
₩292,016
500 G
₩469,438

About This Item

Linear Formula:
(C6H10O2)n
UNSPSC 코드:
12162002
NACRES:
NA.23

₩107,184

재고 있음세부사항

벌크 견적 요청

양식

pellets (~3 mm)

Quality Level

200

분자량

average Mn 80,000

환경친화적 대안 제품 특성

Design for Energy Efficiency
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

불순물

<0.5% water

mp

60 °C (lit.)

density

1.145 g/mL at 25 °C

Mw/Mn

<2

응용 분야

3D bioprinting
advanced drug delivery

환경친화적 대안 카테고리

Enabling

SMILES string

C1CCC(=O)OCC1 (Canonical-SMILES)

InChI

1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2

InChI key

PAPBSGBWRJIAAV-UHFFFAOYSA-N

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관련 카테고리

일반 설명

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
  • It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
  • Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.[1]
We are committed to bringing you Greener Alternative Products, which belongs to one of the four categories of greener alternatives. This is an enabling product that belongs to a family of high-performance bio-based polymers that are essential for developing efficient, low-cost, and environmentally friendly renewable energy solutions. Click here for more information.

애플리케이션

  • PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
  • Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.[1]
  • PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
  • Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.[2]
  • Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.

특징 및 장점

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000407025
0000366293
0000345170
0000342370
0000306693

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COA 검색

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 1

1 of 1

Resomer&#174; C 209, Poly(caprolactone) ester terminated

Sigma-Aldrich

769762

Resomer® C 209, Poly(caprolactone)

Hung-Jen Shao et al.
Journal of biomedical materials research. Part A, 100(12), 3344-3352 (2012-06-27)
The phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) on different ratio of chitosan/polycaprolactone (PCL) blends were investigated in this study. The results showed that hBMSCs existed different morphology on chitosan/PCL blends due to the different adhesion characteristic of
Cevat Erisken et al.
Tissue engineering. Part A, 17(9-10), 1239-1252 (2010-12-30)
The ability to fabricate tissue engineering scaffolds containing systematic gradients in the distributions of stimulators provides additional means for the mimicking of the important gradients observed in native tissues. Here the concentration distributions of two bioactive agents were varied concomitantly
Muhammad Shafiq et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(7), e117-e134 (2018-06-02)
The objective of this study was to develop small-diameter vascular grafts capable of eluting SDF (stromal cell-derived factor)-1α-derived peptide and SP (substance P) for in situ vascular regeneration. Polycaprolactone (PCL)/collagen grafts containing SP or SDF-1α-derived peptide were fabricated by electrospinning.
T Limongi et al.
Molecular neurobiology, 55(12), 8788-8798 (2018-03-31)
Biopolymers are increasingly employed for neuroscience applications as scaffolds to drive and promote neural regrowth, thanks to their ability to mediate the upload and subsequent release of active molecules and drugs. Synthetic degradable polymers are characterized by different responses ranging
Wendi Zhang et al.
Biomaterials, 34(27), 6495-6503 (2013-06-04)
Coating the polycation/DNA binary complexes with PEGylated polyanions can improve long-circulation and biocompatibility in vivo. However, it has been certificated PEG dilemma can reduces gene transfection efficiency because of inhibition in cellular uptake and endosomal escape. Herein, two PEGylated anionic
모든 관련된 서류 보기

문서

Bioprinting for Tissue Engineering and Regenerative Medicine

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

Biodegradable Aliphatic Polyesters for Drug Delivery

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

질문

1–5 / 5 질문  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 답변

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Could you please provide the processing parameters for product 440744?

    1 답변

    1. The production process is proprietary. However, the product is a homopolymer of ε-caprolactone with a concentration of ester bond at 610 - 615 M. It has a hydroxyl end group and a melting range of 58 - 60 °C.

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  4. I would like to know the standard curve of UV-vis absorbance of polycaprolactone.

    1 답변

    1. This product is not tested for data for UV-Vis absorbance, but one source shows it here: https://www.researchgate.net/figure/A-UV-vis-spectra-of-polycaprolactone-PCL-and-aminolysed-PCL-samples-Right-panel_fig4_319107535

      Please note, the curve cannot be guaranteed as this is not something that is tested internally.

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  5. What are the processing parameters for the product?

    1 답변

    1. The production process is considered proprietary, however the following details may be shared: The product is a homopolymer of ε-caprolactone The concentration of ester bond is 610 - 615 M. The product has a hydroxyl end group. The melting range is 58 - 60 °C.

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