Epigenetics

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표시 1-12 of 12 결과

Epigenetic regulation starts with DNA wound around a set of completely acetylated histones associated with an activated, fully transcribed gene.

Agarose Beads Vs. Magnetic Beads in ChIP

Agarose beads Vs. Magnetic beads in Chromatin Immunoprecipitation (ChIP)

Guides to Cell Number for ChIP and Endpoint Analysis

Guides to cell number for Chromatin Immunoprecipitation (ChIP) and endpoint analysis

Chromatin Immunoprecipitation (ChIP) Troubleshooting

Get answers to frequently asked questions about chromatin immunoprecipitation (ChIP), including issues with sonication and DNA shearing.

Chromatin Immunoprecipitation (ChIP)

Choosing the right ChIP antibody is crucial for successful experiments, even with high-quality antibodies validated for Western blot.

Global DNA Methylation Quantification

Global DNA Modification Kit (MDQ1) monitors DNA methylation via sandwich ELISA-like assay, aiding in epigenetic research.

p53: DNA Damage Response and Cancer

p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

ChIP-X: Cross-linking proteins to DNA and cell lysis

X-ChIP: Cross-linking proteins to DNA and cell lysis

Fragmentation of chromatin in ChIP

Fragmentation of chromatin in Chromatin Immunoprecipitation (ChIP)

Epigenetics Overview

Epigenetics is a term coined to describe changes that are not mutation based but can still be passed on from generation to generation. Genes that are activated or repressed without any change in DNA sequence are epigenetically controlled. Epigenetic modifications

DNA Methylation & Bisulfite Conversion

Bisulfite treatment distinguishes methylated DNA in gene methylation studies, exploiting the stability of methylated cytosine.