- Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.
Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy (2008-08-30)
S Page, F Vernel-Pauillac, O O'Connor, S Bremont, F Charavay, P Courvalin, C Goarant, S Le Hello
PMID18725440
ABSTRACT
Fluoroquinolone resistance in Streptococcus pneumoniae mainly involves stepwise mutations predominantly in the parC and gyrA genes. We have developed a single-run real-time PCR assay for detection of the four most common mutations in the quinolone resistance-determining regions of these genes. This assay provides a useful tool for both clinical and epidemiological use.
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