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  • 1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.

1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.

Current drug discovery technologies (2007-11-30)
Huiming Jiang, Shufen Zhang, Qinglin Guan, Chang Chen, Fan Gao, Yang Zhang
ABSTRACT

The inclusion complex between beta-CD and 1-hexadecanol is synthesized and identified via (1)H NMR spectrum. The possible conformation of the inclusion complex is figured out. Via MM2 calculations, the possibility of complexation is verified.

MATERIALS
Product Number
Brand
Product Description

Cetyl alcohol, European Pharmacopoeia (EP) Reference Standard
Supelco
Cetyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Cetyl alcohol, analytical standard
Sigma-Aldrich
1-Hexadecanol, 95%
Sigma-Aldrich
1-Hexadecanol, ≥99%
Sigma-Aldrich
1-Hexadecanol, ReagentPlus®, 99%