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  • Analogs of arginine vasopressin modified in position 3 with (R)-alpha-hydroxymethylphenylalanine.

Analogs of arginine vasopressin modified in position 3 with (R)-alpha-hydroxymethylphenylalanine.

The journal of peptide research : official journal of the American Peptide Society (1999-07-29)
E Lempicka, J Slaninova, A Olma, B Lammek
PMID10424351
ABSTRACT

This study describes the synthesis and some pharmacological properties of three new analogs of arginine vasopressin (AVP) substituted in position 3 with (R)-alpha-hydroxymethylphenylalanine ([R]-HmPhe). All new peptides were tested for vasopressor and antidiuretic as well as uterotonic activity. None of the 3 analogs showed any pressor activity and their uterotonic activity was negligible. Only analog [Mpa1,(R)-HmPhe3]AVP exhibited significant antidiuretic activity.